{"entity":{"id":"cnksr2","kind":"target","name":"CNKSR2","aka":["connector enhancer of kinase suppressor of Ras 2","Connector enhancer of kinase suppressor of ras 2","KIAA0902","CNK2","KSR2"],"tldr":"CNKSR2 (Connector enhancer of kinase suppressor of ras 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"May function as an adapter protein or regulator of Ras signalling pathways.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.90, affected pathway 0.97, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:19701","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19701"},{"label":"UniProt Q8WXI2","url":"https://www.uniprot.org/uniprotkb/Q8WXI2/entry"},{"label":"NCBI Gene 22866","url":"https://www.ncbi.nlm.nih.gov/gene/22866"},{"label":"Ensembl ENSG00000149970","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000149970"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CNKSR2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:19701","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19701","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8WXI2","url":"https://www.uniprot.org/uniprotkb/Q8WXI2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000149970","url":"https://platform.opentargets.org/target/ENSG00000149970/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"}],"hgnc":"HGNC:19701","ensembl":"ENSG00000149970","uniprot":"Q8WXI2","entrez":"22866","biology":"May function as an adapter protein or regulator of Ras signalling pathways. Location: Cytoplasm; Membrane (UniProt). Locus Xp22.12 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/cnksr2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}