{"entity":{"id":"cnot9","kind":"target","name":"CNOT9","aka":["CCR4-NOT transcription complex subunit 9","RCD1","RCD1+","CT129","CAF40","RQCD1"],"tldr":"CNOT9 (CCR4-NOT transcription complex subunit 9) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Melanoma.","summary":"Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription.\n\nIntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Melanoma, Cutaneous Melanoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10445","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10445"},{"label":"UniProt Q92600","url":"https://www.uniprot.org/uniprotkb/Q92600/entry"},{"label":"NCBI Gene 9125","url":"https://www.ncbi.nlm.nih.gov/gene/9125"},{"label":"Ensembl ENSG00000144580","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000144580"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CNOT9","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:10445","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10445","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q92600","url":"https://www.uniprot.org/uniprotkb/Q92600/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen CNOT9","url":"https://www.intogen.org/search?gene=CNOT9","note":"driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:10445","ensembl":"ENSG00000144580","uniprot":"Q92600","entrez":"9125","biology":"Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation. Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Location: Nucleus; Cytoplasm, P-body (UniProt). Locus 2q35 (HGNC).","whereFound":["Melanoma: IntOGen driver in 2 cohorts (MEL, SKCM)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/cnot9/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}]}}