{"entity":{"id":"cntrl","kind":"target","name":"CNTRL","aka":["centriolin","Centriolin","CEP1","CEP110"],"tldr":"CNTRL (Centriolin) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Leukaemia, Nasopharyngeal carcinoma, Cutaneous squamous cell carcinoma and 1 more.","summary":"Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission.\n\nOpen Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.71, affected pathway 0.94, genetic association 0.00, somatic mutation 0.45). IntOGen calls it a driver in 3 cohorts (1 activating, 2 loss-of-function), covering Cutaneous Squamous Cell Carcinoma, Nasopharyngeal Carcinoma, Thymoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:1858","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1858"},{"label":"UniProt Q7Z7A1","url":"https://www.uniprot.org/uniprotkb/Q7Z7A1/entry"},{"label":"NCBI Gene 11064","url":"https://www.ncbi.nlm.nih.gov/gene/11064"},{"label":"Ensembl ENSG00000119397","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000119397"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["leukaemia","nasopharyngeal","cutaneous-scc","thymoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CNTRL","role":["oncogene-driver","tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:1858","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1858","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q7Z7A1","url":"https://www.uniprot.org/uniprotkb/Q7Z7A1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000119397","url":"https://platform.opentargets.org/target/ENSG00000119397/associations","note":"association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: leukaemia 0.57 (GraphQL API, CC0)"},{"label":"IntOGen CNTRL","url":"https://www.intogen.org/search?gene=CNTRL","note":"driver in 3 cohorts (Act 1, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:1858","ensembl":"ENSG00000119397","uniprot":"Q7Z7A1","entrez":"11064","biology":"Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Midbody, Midbody ring (UniProt). Locus 9q33.2 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.57 with leukaemia (MONDO_0005059)","Nasopharyngeal carcinoma: IntOGen driver in 1 cohort (NPC)","Cutaneous squamous cell carcinoma: IntOGen driver in 1 cohort (CSCC)","Thymoma: IntOGen driver in 1 cohort (THYM)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/cntrl/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"cutaneous-scc","kind":"cancer","name":"Cutaneous squamous cell carcinoma","route":"/cancers/cutaneous-scc/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"nasopharyngeal","kind":"cancer","name":"Nasopharyngeal carcinoma","route":"/cancers/nasopharyngeal/"},{"id":"thymoma","kind":"cancer","name":"Thymoma (WHO types A, AB, B1, B2 and B3)","route":"/cancers/thymoma/"}]}}