{"entity":{"id":"col6a3","kind":"target","name":"COL6A3","aka":["collagen type VI alpha 3 chain","Collagen alpha-3(VI) chain"],"tldr":"COL6A3 (Collagen alpha-3(VI) chain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a drug target and a tumour suppressor, and an approved or late-stage drug is recorded against it. Tied to Melanoma.","summary":"Collagen VI acts as a cell-binding protein.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Melanoma. In OnCo, 1 product record names it (Vimseltinib).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2213","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2213"},{"label":"UniProt P12111","url":"https://www.uniprot.org/uniprotkb/P12111/entry"},{"label":"NCBI Gene 1293","url":"https://www.ncbi.nlm.nih.gov/gene/1293"},{"label":"Ensembl ENSG00000163359","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163359"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":["vimseltinib"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: 1 OnCo product record names it; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"COL6A3","role":["drug-target","tumour-suppressor"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:2213","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2213","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P12111","url":"https://www.uniprot.org/uniprotkb/P12111/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen COL6A3","url":"https://www.intogen.org/search?gene=COL6A3","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:2213","ensembl":"ENSG00000163359","uniprot":"P12111","entrez":"1293","biology":"Collagen VI acts as a cell-binding protein. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 2q37.3 (HGNC).","whereFound":["Melanoma: IntOGen driver in 1 cohort (MEL)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/col6a3/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}],"drug":[{"id":"vimseltinib","kind":"drug","name":"Vimseltinib","route":"/drugs/vimseltinib/"}]}}