{"entity":{"id":"col6a6","kind":"target","name":"COL6A6","aka":["collagen type VI alpha 6 chain","Collagen alpha-6(VI) chain"],"tldr":"COL6A6 (Collagen alpha-6(VI) chain) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.","summary":"Collagen VI acts as a cell-binding protein.\n\nIntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pancreatic Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:27023","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:27023"},{"label":"UniProt A6NMZ7","url":"https://www.uniprot.org/uniprotkb/A6NMZ7/entry"},{"label":"NCBI Gene 131873","url":"https://www.ncbi.nlm.nih.gov/gene/131873"},{"label":"Ensembl ENSG00000206384","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000206384"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["pancreatic"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"COL6A6","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:27023","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:27023","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt A6NMZ7","url":"https://www.uniprot.org/uniprotkb/A6NMZ7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen COL6A6","url":"https://www.intogen.org/search?gene=COL6A6","note":"driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:27023","ensembl":"ENSG00000206384","uniprot":"A6NMZ7","entrez":"131873","biology":"Collagen VI acts as a cell-binding protein. Location: Secreted, extracellular space, extracellular matrix (UniProt). Locus 3q22.1 (HGNC).","whereFound":["Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/col6a6/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}]}}