{"entity":{"id":"contrast-enhanced-mammography","kind":"technology","name":"Contrast-enhanced mammography","aka":[],"tldr":"A mammogram taken after an iodine contrast injection, at two X-ray energies, so that a tumour's blood supply shows up as a bright spot. It gives much of what breast MRI gives on a machine most breast units already own.","summary":"Contrast-enhanced mammography adds an intravenous iodinated contrast injection to a digital mammography unit fitted with dual-energy software: a low- and a high-energy exposure are taken in each view a couple of minutes after injection and subtracted to leave an image of where contrast has pooled, which is where tumours have recruited blood vessels. Hologic (I-View), GE HealthCare (SenoBright HD), Siemens Healthineers (TiCEM) and Fujifilm offer it on their platforms, and contrast-guided biopsy devices followed. It is used to stage newly diagnosed cancers and measure their extent, to solve inconclusive findings on mammography and ultrasound, to monitor response to pre-operative chemotherapy, and, in trials such as CMIST, as a supplemental screening test for women with dense breasts. Its accuracy approaches that of breast MRI for detecting cancer and measuring size, in a ten-minute examination on existing equipment.\n\nThe costs are an iodine injection with its small risk of reaction and kidney concerns, a radiation dose somewhat higher than a standard mammogram, compression as in mammography, no view of the axilla or the chest wall, and less evidence than MRI in high-risk screening. Where MRI capacity is scarce, contrast mammography is the practical alternative.","status":"established","asOf":"2026-09-17","wikipedia":"https://en.wikipedia.org/wiki/Contrast-enhanced_spectral_mammography","links":[{"label":"Jochelson and Lobbes, Contrast-enhanced mammography: state of the art (Radiology 2021)","url":"https://doi.org/10.1148/radiol.2021201948"},{"label":"Hologic: I-View contrast enhanced imaging","url":"https://www.hologic.com/hologic-products/breast-health-solutions/i-view-contrast-enhanced-imaging"}],"tags":["machines-wave2"],"related":["ultrasound-elastography-ceus","radiology-ai-screening"],"cancers":["breast-cancer","dcis"],"sections":["imaging","early-detection"],"technologies":["mammography","breast-mri-coils-abbreviated-mri","ai-mammography-screening","dual-energy-spectral-ct"],"targets":[],"drugs":[],"companies":["hologic","ge-healthcare","siemens-healthineers","fujifilm"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"principle":"Dual-energy digital mammography acquired after intravenous iodinated contrast is recombined to suppress normal tissue and display iodine uptake, mapping tumour neovascularity on standard mammographic views.","strengths":["Accuracy close to breast MRI for detection and size","Ten-minute examination on existing mammography units","Cheaper and more available than MRI"],"limitations":["Iodine contrast risks","Higher radiation dose than standard mammography","Does not image the axilla or chest wall"],"since":2011},"route":"/technologies/contrast-enhanced-mammography/","neighbours":{"technology":[{"id":"radiology-ai-screening","kind":"technology","name":"AI in radiology","route":"/technologies/radiology-ai-screening/"},{"id":"ai-mammography-screening","kind":"technology","name":"AI-assisted mammography screening","route":"/technologies/ai-mammography-screening/"},{"id":"breast-mri-coils-abbreviated-mri","kind":"technology","name":"Breast MRI coils and abbreviated breast MRI","route":"/technologies/breast-mri-coils-abbreviated-mri/"},{"id":"dual-energy-spectral-ct","kind":"technology","name":"Dual-energy and spectral CT","route":"/technologies/dual-energy-spectral-ct/"},{"id":"ultrasound-elastography-ceus","kind":"technology","name":"Elastography and contrast-enhanced ultrasound","route":"/technologies/ultrasound-elastography-ceus/"},{"id":"mammography","kind":"technology","name":"Mammography & tomosynthesis","route":"/technologies/mammography/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}],"term":[{"id":"dcis","kind":"term","name":"Ductal carcinoma in situ (DCIS)","route":"/terms/dcis/"}],"section":[{"id":"early-detection","kind":"section","name":"Early Detection & Screening","route":"/fronts/early-detection/"},{"id":"imaging","kind":"section","name":"Imaging","route":"/fronts/imaging/"}],"company":[{"id":"fujifilm","kind":"company","name":"FUJIFILM Healthcare","route":"/companies/fujifilm/"},{"id":"ge-healthcare","kind":"company","name":"GE HealthCare","route":"/companies/ge-healthcare/"},{"id":"hologic","kind":"company","name":"Hologic","route":"/companies/hologic/"},{"id":"siemens-healthineers","kind":"company","name":"Siemens Healthineers","route":"/companies/siemens-healthineers/"}]}}