{"entity":{"id":"cpeb3","kind":"target","name":"CPEB3","aka":["cytoplasmic polyadenylation element binding protein 3","Cytoplasmic polyadenylation element-binding protein 3","KIAA0940"],"tldr":"CPEB3 (Cytoplasmic polyadenylation element-binding protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Basal cell carcinoma.","summary":"Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator. In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure. Required for the consolidation and maintenance of hippocampal-based long term memory.\n\nIntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Basal Cell Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:21746","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21746"},{"label":"UniProt Q8NE35","url":"https://www.uniprot.org/uniprotkb/Q8NE35/entry"},{"label":"NCBI Gene 22849","url":"https://www.ncbi.nlm.nih.gov/gene/22849"},{"label":"Ensembl ENSG00000107864","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000107864"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["basal-cell-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CPEB3","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:21746","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:21746","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q8NE35","url":"https://www.uniprot.org/uniprotkb/Q8NE35/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen CPEB3","url":"https://www.intogen.org/search?gene=CPEB3","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:21746","ensembl":"ENSG00000107864","uniprot":"Q8NE35","entrez":"22849","biology":"Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator. In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure. Required for the consolidation and maintenance of hippocampal-based long term memory. In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation. Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B. When activated, acts as a translational activator of GRIA1 and GRIA2. Location: Cytoplasm; Nucleus; Synapse; Cell projection, dendrite (UniProt). Locus 10q23.32 (HGNC).","whereFound":["Basal cell carcinoma: IntOGen driver in 1 cohort (BCC)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/cpeb3/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"}]}}