{"entity":{"id":"cpsf6","kind":"target","name":"CPSF6","aka":["cleavage and polyadenylation specific factor 6","Cleavage and polyadenylation specificity factor subunit 6","HPBRII-4","HPBRII-7","CFIM68","CFIM72"],"tldr":"CPSF6 (Cleavage and polyadenylation specificity factor subunit 6) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Leukaemia.","summary":"Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation.\n\nOpen Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.94, genetic association 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:13871","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13871"},{"label":"UniProt Q16630","url":"https://www.uniprot.org/uniprotkb/Q16630/entry"},{"label":"NCBI Gene 11052","url":"https://www.ncbi.nlm.nih.gov/gene/11052"},{"label":"Ensembl ENSG00000111605","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000111605"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["leukaemia"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CPSF6","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:13871","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13871","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q16630","url":"https://www.uniprot.org/uniprotkb/Q16630/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000111605","url":"https://platform.opentargets.org/target/ENSG00000111605/associations","note":"association with cancer (MONDO_0004992) 0.60; per-cancer scores at or above 0.5: leukaemia 0.52 (GraphQL API, CC0)"}],"hgnc":"HGNC:13871","ensembl":"ENSG00000111605","uniprot":"Q16630","entrez":"11052","biology":"Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localised in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. CPSF6 enhances NUDT21/CPSF5 binding to 5'-UGUA-3' elements localised upstream of pA signals and promotes RNA looping, and hence activates directly the mRNA 3'-processing machinery. Plays a role in mRNA export. Location: Nucleus; Nucleus, nucleoplasm; Nucleus speckle; Cytoplasm (UniProt). Locus 12q15 (HGNC).","whereFound":["Leukaemia: Open Targets association 0.52 with leukaemia (MONDO_0005059)"],"targetClass":"other","prevalence":[]},"route":"/targets/cpsf6/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"}]}}