{"entity":{"id":"cpvl","kind":"target","name":"CPVL","aka":["carboxypeptidase vitellogenic like","Probable serine carboxypeptidase CPVL"],"tldr":"CPVL (Probable serine carboxypeptidase CPVL) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer and Basal cell carcinoma.","summary":"May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation.\n\nOpen Targets scores its association with cancer at 0.61 (direct and indirect evidence; datatypes literature 0.86, animal model 0.57, genetic association 0.75).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:14399","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14399"},{"label":"UniProt Q9H3G5","url":"https://www.uniprot.org/uniprotkb/Q9H3G5/entry"},{"label":"NCBI Gene 54504","url":"https://www.ncbi.nlm.nih.gov/gene/54504"},{"label":"Ensembl ENSG00000106066","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000106066"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["skin-cancer","basal-cell-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CPVL","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:14399","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14399","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9H3G5","url":"https://www.uniprot.org/uniprotkb/Q9H3G5/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000106066","url":"https://platform.opentargets.org/target/ENSG00000106066/associations","note":"association with cancer (MONDO_0004992) 0.61; per-cancer scores at or above 0.5: skin cancer 0.57, basal cell carcinoma 0.55 (GraphQL API, CC0)"}],"hgnc":"HGNC:14399","ensembl":"ENSG00000106066","uniprot":"Q9H3G5","entrez":"54504","biology":"May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation. Locus 7p14.3 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.57 with skin cancer (MONDO_0002898)","Basal cell carcinoma: Open Targets association 0.55 with basal cell carcinoma (MONDO_0020804)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/cpvl/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}