{"entity":{"id":"creb1","kind":"target","name":"CREB1","aka":["cAMP responsive element binding protein 1","Cyclic AMP-responsive element-binding protein 1"],"tldr":"CREB1 (Cyclic AMP-responsive element-binding protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer, Sarcomas, Skin cancer and 1 more.","summary":"Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronisation of circadian rhythmicity and the differentiation of adipose cells.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.99, animal model 0.57, genetic association 0.00, somatic mutation 0.97).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2345","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2345"},{"label":"UniProt P16220","url":"https://www.uniprot.org/uniprotkb/P16220/entry"},{"label":"NCBI Gene 1385","url":"https://www.ncbi.nlm.nih.gov/gene/1385"},{"label":"Ensembl ENSG00000118260","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000118260"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer","sarcoma","skin-cancer","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CREB1","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:2345","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2345","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P16220","url":"https://www.uniprot.org/uniprotkb/P16220/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000118260","url":"https://platform.opentargets.org/target/ENSG00000118260/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: melanoma 0.52, sarcoma 0.52, skin cancer 0.51, breast cancer 0.52 (GraphQL API, CC0)"}],"hgnc":"HGNC:2345","ensembl":"ENSG00000118260","uniprot":"P16220","entrez":"1385","biology":"Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-119 phosphorylation. Involved in different cellular processes including the synchronisation of circadian rhythmicity and the differentiation of adipose cells. Regulates the expression of apoptotic and inflammatory response factors in cardiomyocytes in response to ERFE-mediated activation of AKT signalling. Location: Nucleus (UniProt). Locus 2q33.3 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.52 with breast cancer (MONDO_0007254)","Sarcomas: Open Targets association 0.52 with sarcoma (MONDO_0005089)","Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)","Melanoma: Open Targets association 0.52 with melanoma (MONDO_0005105)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/creb1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}