{"entity":{"id":"creb3l1","kind":"target","name":"CREB3L1","aka":["cAMP responsive element binding protein 3 like 1","Cyclic AMP-responsive element-binding protein 3-like protein 1","OASIS"],"tldr":"CREB3L1 (Cyclic AMP-responsive element-binding protein 3-like protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas, Lung cancer and Breast cancer.","summary":"Precursor of the transcription factor form (Processed cyclic AMP-responsive element-binding protein 3-like protein 1), which is embedded in the endoplasmic reticulum membrane with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress or DNA damage, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus where it activates transcription of specific target genes involved in the cell-cycle progression inhibition.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.00, somatic mutation 0.98).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18856","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18856"},{"label":"UniProt Q96BA8","url":"https://www.uniprot.org/uniprotkb/Q96BA8/entry"},{"label":"NCBI Gene 90993","url":"https://www.ncbi.nlm.nih.gov/gene/90993"},{"label":"Ensembl ENSG00000157613","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000157613"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["sarcoma","lung-cancer","breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CREB3L1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:18856","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18856","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q96BA8","url":"https://www.uniprot.org/uniprotkb/Q96BA8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000157613","url":"https://platform.opentargets.org/target/ENSG00000157613/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: sarcoma 0.59, breast cancer 0.51, lung cancer 0.51 (GraphQL API, CC0)"}],"hgnc":"HGNC:18856","ensembl":"ENSG00000157613","uniprot":"Q96BA8","entrez":"90993","biology":"Precursor of the transcription factor form (Processed cyclic AMP-responsive element-binding protein 3-like protein 1), which is embedded in the endoplasmic reticulum membrane with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress or DNA damage, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus where it activates transcription of specific target genes involved in the cell-cycle progression inhibition. Transcription factor involved in cell type specific DNA damage and unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3'. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Location: Endoplasmic reticulum membrane; Nucleus (UniProt). Locus 11p11.2 (HGNC).","whereFound":["Sarcomas: Open Targets association 0.59 with sarcoma (MONDO_0005089)","Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)","Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/creb3l1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}