{"entity":{"id":"creb3l2","kind":"target","name":"CREB3L2","aka":["cAMP responsive element binding protein 3 like 2","Cyclic AMP-responsive element-binding protein 3-like protein 2","BBF2H7","TCAG_1951439"],"tldr":"CREB3L2 (Cyclic AMP-responsive element-binding protein 3-like protein 2) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas, Breast cancer and Lung cancer.","summary":"Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.85, animal model 0.54, genetic association 0.00, somatic mutation 0.98).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:23720","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23720"},{"label":"UniProt Q70SY1","url":"https://www.uniprot.org/uniprotkb/Q70SY1/entry"},{"label":"NCBI Gene 64764","url":"https://www.ncbi.nlm.nih.gov/gene/64764"},{"label":"Ensembl ENSG00000182158","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000182158"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["sarcoma","breast-cancer","lung-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CREB3L2","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:23720","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23720","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q70SY1","url":"https://www.uniprot.org/uniprotkb/Q70SY1/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000182158","url":"https://platform.opentargets.org/target/ENSG00000182158/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: sarcoma 0.58, breast cancer 0.51, lung cancer 0.50 (GraphQL API, CC0)"}],"hgnc":"HGNC:23720","ensembl":"ENSG00000182158","uniprot":"Q70SY1","entrez":"64764","biology":"Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes. In a neuroblastoma cell line, protects cells from ER stress-induced death. Location: Endoplasmic reticulum membrane; Nucleus (UniProt). Locus 7q33 (HGNC).","whereFound":["Sarcomas: Open Targets association 0.58 with sarcoma (MONDO_0005089)","Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)","Lung cancer: Open Targets association 0.50 with lung cancer (MONDO_0008903)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/creb3l2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}