{"entity":{"id":"crg-023","kind":"drug","name":"CRG-023","aka":[],"tldr":"CRG-023 is an experimental autologous tri-specific CAR T-cell therapy from CARGO Therapeutics, in preclinical development for large B-cell lymphoma; its current status is not stated.","summary":"CRG-023 is an autologous tri-specific CAR T-cell therapy from CARGO Therapeutics. T cells carrying three separate CARs against CD19, CD20 and CD22 expressed from one lentiviral vector, each with its own co-stimulatory domain, including a CD2 co-stimulatory domain. Its furthest stage is preclinical development, for large B-cell lymphoma. No clinical trial naming it is registered on ClinicalTrials.gov. FDA allowed the IND in January 2025; in March 2025 the board suspended various development efforts and the company was later acquired. No trial registered. It has not been shown to work in people.","status":"preclinical","asOf":"2026-11-03","links":[{"label":"CARGO Therapeutics: sec.gov","url":"https://www.sec.gov/Archives/edgar/data/1966494/000095017025066940/crgx-20250331.htm"},{"label":"CARGO Therapeutics: sec.gov","url":"https://www.sec.gov/Archives/edgar/data/1966494/000095017025066940/crgx-20250331.htm"}],"tags":["pipeline"],"related":[],"cancers":[],"sections":[],"technologies":[],"targets":["cd19","cd20","cd22"],"drugs":[],"companies":["cargo-therapeutics"],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo gap audit, class 5 (company pipeline pages and ClinicalTrials.gov v2)","editedOn":"2026-11-03"},"code":"CRG-023","modality":"Autologous tri-specific CAR T-cell therapy","mechanism":"T cells carrying three separate CARs against CD19, CD20 and CD22 expressed from one lentiviral vector, each with its own co-stimulatory domain, including a CD2 co-stimulatory domain.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/crg-023/","neighbours":{"target":[{"id":"cd19","kind":"target","name":"CD19","route":"/targets/cd19/"},{"id":"cd20","kind":"target","name":"CD20","route":"/targets/cd20/"},{"id":"cd22","kind":"target","name":"CD22","route":"/targets/cd22/"}],"company":[{"id":"cargo-therapeutics","kind":"company","name":"CARGO Therapeutics","route":"/companies/cargo-therapeutics/"}]}}