{"entity":{"id":"crtc1","kind":"target","name":"CRTC1","aka":["CREB regulated transcription coactivator 1","CREB-regulated transcription coactivator 1","KIAA0616","FLJ14027","TORC1","MECT1"],"tldr":"CRTC1 (CREB-regulated transcription coactivator 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Salivary gland cancers, Lung cancer, Skin cancer and 5 more.","summary":"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signalling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4.\n\nOpen Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.82, animal model 0.26, genetic association 0.26, somatic mutation 0.84). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Adenoid Cystic Carcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:16062","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16062"},{"label":"UniProt Q6UUV9","url":"https://www.uniprot.org/uniprotkb/Q6UUV9/entry"},{"label":"NCBI Gene 23373","url":"https://www.ncbi.nlm.nih.gov/gene/23373"},{"label":"Ensembl ENSG00000105662","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000105662"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["salivary-gland","lung-cancer","skin-cancer","colorectal","esophageal","mucoepidermoid-carcinoma","adenoid-cystic-carcinoma","oral-cavity-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CRTC1","role":["oncogene-driver","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:16062","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16062","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6UUV9","url":"https://www.uniprot.org/uniprotkb/Q6UUV9/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000105662","url":"https://platform.opentargets.org/target/ENSG00000105662/associations","note":"association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: non-small cell lung carcinoma 0.54, colorectal cancer 0.51, oesophageal cancer 0.51, skin cancer 0.51, lung cancer 0.56, oral cavity cancer 0.56 (GraphQL API, CC0)"},{"label":"IntOGen CRTC1","url":"https://www.intogen.org/search?gene=CRTC1","note":"driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:16062","ensembl":"ENSG00000105662","uniprot":"Q6UUV9","entrez":"23373","biology":"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signalling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. Location: Cytoplasm; Nucleus (UniProt). Locus 19p13.11 (HGNC).","whereFound":["Salivary gland cancers: IntOGen driver in 1 cohort (ACYC)","Lung cancer: Open Targets association 0.56 with lung cancer (MONDO_0008903)","Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)","Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)","Oesophageal cancer: Open Targets association 0.51 with oesophageal cancer (MONDO_0007576)","Mucoepidermoid carcinoma: Open Targets association 0.58 with mucoepidermoid carcinoma (MONDO_0003036)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/crtc1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"adenoid-cystic-carcinoma","kind":"cancer","name":"Adenoid cystic carcinoma","route":"/cancers/adenoid-cystic-carcinoma/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"mucoepidermoid-carcinoma","kind":"cancer","name":"Mucoepidermoid carcinoma","route":"/cancers/mucoepidermoid-carcinoma/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"oral-cavity-cancer","kind":"cancer","name":"Oral cavity cancer (mouth and tongue)","route":"/cancers/oral-cavity-cancer/"},{"id":"salivary-gland","kind":"cancer","name":"Salivary gland cancers","route":"/cancers/salivary-gland/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}