{"entity":{"id":"crtc3","kind":"target","name":"CRTC3","aka":["CREB regulated transcription coactivator 3","CREB-regulated transcription coactivator 3","FLJ21868"],"tldr":"CRTC3 (CREB-regulated transcription coactivator 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.","summary":"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signalling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4.\n\nOpen Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.68, genetic association 0.31, somatic mutation 0.78).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:26148","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:26148"},{"label":"UniProt Q6UUV7","url":"https://www.uniprot.org/uniprotkb/Q6UUV7/entry"},{"label":"NCBI Gene 64784","url":"https://www.ncbi.nlm.nih.gov/gene/64784"},{"label":"Ensembl ENSG00000140577","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000140577"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["oral-cavity-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CRTC3","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:26148","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:26148","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q6UUV7","url":"https://www.uniprot.org/uniprotkb/Q6UUV7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000140577","url":"https://platform.opentargets.org/target/ENSG00000140577/associations","note":"association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: oral cavity cancer 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:26148","ensembl":"ENSG00000140577","uniprot":"Q6UUV7","entrez":"64784","biology":"Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signalling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukaemia virus type 1 (HTLV-1) long terminal repeats (LTR). Location: Nucleus; Cytoplasm (UniProt). Locus 15q26.1 (HGNC).","whereFound":["Oral cavity cancer: Open Targets association 0.53 with oral cavity cancer (MONDO_0005515)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/crtc3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"oral-cavity-cancer","kind":"cancer","name":"Oral cavity cancer (mouth and tongue)","route":"/cancers/oral-cavity-cancer/"}]}}