{"entity":{"id":"csf2ra","kind":"target","name":"GM-CSF receptor (CSF2RA)","aka":[],"tldr":"The GM-CSF receptor is what sargramostim switches on to speed the recovery of white cells after leukaemia chemotherapy and stem cell transplantation, and it is the signal that tumour vaccines such as talimogene use to recruit immune cells.","summary":"The granulocyte-macrophage colony-stimulating factor receptor is made of a ligand-binding alpha chain (CSF2RA) and the common beta chain shared with the IL-3 and IL-5 receptors. Recombinant GM-CSF (sargramostim, Leukine) is approved to shorten neutrophil recovery after induction chemotherapy for acute myeloid leukaemia and after autologous and allogeneic stem cell transplantation, and to mobilise stem cells. GM-CSF is also encoded into talimogene laherparepvec and several cancer vaccines to attract and mature dendritic cells at the tumour site, while the receptor itself is a marker on juvenile myelomonocytic leukaemia cells.","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/GM-CSF_receptor","links":[{"label":"UniProt P15509: CSF2RA","url":"https://www.uniprot.org/uniprotkb/P15509/entry"},{"label":"HGNC:2435 CSF2RA","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2435"},{"label":"ChEMBL target CHEMBL2364169","url":"https://www.ebi.ac.uk/chembl/explore/target/CHEMBL2364169"}],"tags":["chembl-gap"],"related":["jak2","csf3r"],"cancers":["aml","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":["talimogene-laherparepvec"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"symbol":"CSF2RA","biology":"A type I cytokine receptor whose beta chain activates JAK2 and STAT5; it drives proliferation and differentiation of granulocyte and macrophage precursors and activates dendritic cells.","whereFound":["Myeloid progenitors, neutrophils, monocytes and dendritic cells","Juvenile myelomonocytic leukaemia and some AML blasts"],"targetClass":"surface-antigen","prevalence":[]},"route":"/targets/csf2ra/","neighbours":{"target":[{"id":"csf3r","kind":"target","name":"G-CSF receptor (CSF3R)","route":"/targets/csf3r/"},{"id":"jak2","kind":"target","name":"JAK2","route":"/targets/jak2/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"}],"drug":[{"id":"talimogene-laherparepvec","kind":"drug","name":"Talimogene laherparepvec","route":"/drugs/talimogene-laherparepvec/"}]}}