{"entity":{"id":"csf2rb","kind":"target","name":"CSF2RB","aka":["colony stimulating factor 2 receptor subunit beta","Cytokine receptor common subunit beta","IL5RB","CD131","betaGMR","IL3RB"],"tldr":"CSF2RB (Cytokine receptor common subunit beta) is a gene. The public catalogues list it as a drug target and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Sarcomas, Leukaemia, Myeloproliferative neoplasms and 1 more.","summary":"Cell surface receptor that plays a role in immune response and controls the production and differentiation of haematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA. In turn, participates in various signalling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Doxorubicin. Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.67, animal model 0.45, genetic association 0.00, clinical 0.86).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2436","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2436"},{"label":"UniProt P32927","url":"https://www.uniprot.org/uniprotkb/P32927/entry"},{"label":"NCBI Gene 1439","url":"https://www.ncbi.nlm.nih.gov/gene/1439"},{"label":"Ensembl ENSG00000100368","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100368"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["sarcoma","leukaemia","myeloproliferative-neoplasms","aml"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.86; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CSF2RB","role":["drug-target","biomarker"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:2436","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2436","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P32927","url":"https://www.uniprot.org/uniprotkb/P32927/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene CSF2RB","url":"https://civicdb.org/features/1237","note":"1 evidence items, 0 assertions, 1 variants; diseases: Sarcoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000100368","url":"https://platform.opentargets.org/target/ENSG00000100368/associations","note":"association with cancer (MONDO_0004992) 0.55; per-cancer scores at or above 0.5: acute myeloid leukaemia 0.52, myeloproliferative neoplasm 0.53, leukaemia 0.54 (GraphQL API, CC0)"}],"hgnc":"HGNC:2436","ensembl":"ENSG00000100368","uniprot":"P32927","entrez":"1439","biology":"Cell surface receptor that plays a role in immune response and controls the production and differentiation of haematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA. In turn, participates in various signalling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway. Location: Membrane (UniProt). Locus 22q12.3 (HGNC).","whereFound":["Sarcomas: CIViC evidence names this disease","Leukaemia: Open Targets association 0.54 with leukaemia (MONDO_0005059)","Myeloproliferative neoplasms: Open Targets association 0.53 with myeloproliferative neoplasm (MONDO_0020076)","Acute myeloid leukaemia: Open Targets association 0.52 with acute myeloid leukaemia (MONDO_0018874)"],"targetClass":"other","prevalence":[]},"route":"/targets/csf2rb/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"aml","kind":"cancer","name":"Acute myeloid leukaemia","route":"/cancers/aml/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}