{"entity":{"id":"csmd3","kind":"target","name":"CSMD3","aka":["CUB and Sushi multiple domains 3","CUB and sushi domain-containing protein 3"],"tldr":"CSMD3 (CUB and sushi domain-containing protein 3) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Hepatocellular carcinoma, Head and neck squamous cell carcinoma and 5 more.","summary":"Involved in dendrite development.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.42, genetic association 0.51, somatic mutation 0.76). IntOGen calls it a driver in 46 cohorts (26 activating, 19 loss-of-function), covering Bladder Urothelial Carcinoma, Invasive Breast Carcinoma, Colon Adenocarcinoma, Colorectal Adenocarcinoma, Oesophageal Adenocarcinoma, Glioblastoma Multiforme and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:19291","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19291"},{"label":"UniProt Q7Z407","url":"https://www.uniprot.org/uniprotkb/Q7Z407/entry"},{"label":"NCBI Gene 114788","url":"https://www.ncbi.nlm.nih.gov/gene/114788"},{"label":"Ensembl ENSG00000164796","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164796"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["prostate","hcc","head-and-neck","gastric","breast-cancer","colorectal","esophageal","urothelial"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 26 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 19 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CSMD3","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:19291","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19291","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q7Z407","url":"https://www.uniprot.org/uniprotkb/Q7Z407/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000164796","url":"https://platform.opentargets.org/target/ENSG00000164796/associations","note":"association with cancer (MONDO_0004992) 0.63;  (GraphQL API, CC0)"},{"label":"IntOGen CSMD3","url":"https://www.intogen.org/search?gene=CSMD3","note":"driver in 46 cohorts (Act 26, LoF 19); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:19291","ensembl":"ENSG00000164796","uniprot":"Q7Z407","entrez":"114788","biology":"Involved in dendrite development. Location: Cell membrane (UniProt). Locus 8q23.3 (HGNC).","whereFound":["Prostate cancer: IntOGen driver in 9 cohorts (PRAD)","Hepatocellular carcinoma: IntOGen driver in 4 cohorts (HCC)","Head and neck squamous cell carcinoma: IntOGen driver in 4 cohorts (HNSC)","Gastric & gastro-oesophageal junction cancer: IntOGen driver in 4 cohorts (STAD)","Breast cancer: IntOGen driver in 3 cohorts (BRCA)","Colorectal cancer: IntOGen driver in 3 cohorts (COAD, COADREAD)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/csmd3/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"urothelial","kind":"cancer","name":"Bladder & urothelial cancer","route":"/cancers/urothelial/"},{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"hcc","kind":"cancer","name":"Hepatocellular carcinoma","route":"/cancers/hcc/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}