{"entity":{"id":"csnk1a1","kind":"target","name":"CSNK1A1","aka":["casein kinase 1 alpha 1","Casein kinase I isoform alpha","CK1","CK1a","CK1alpha","CKIa","CKIalpha"],"tldr":"CSNK1A1 (Casein kinase I isoform alpha) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Casein kinases are operationally defined by their preferential utilisation of acidic proteins such as caseins as substrates. Phosphorylates a large number of proteins. Participates in Wnt signalling.\n\nOpen Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.96, affected pathway 0.89, genetic association 0.17, somatic mutation 0.00).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2451","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2451"},{"label":"UniProt P48729","url":"https://www.uniprot.org/uniprotkb/P48729/entry"},{"label":"NCBI Gene 1452","url":"https://www.ncbi.nlm.nih.gov/gene/1452"},{"label":"Ensembl ENSG00000113712","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000113712"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CSNK1A1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:2451","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2451","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P48729","url":"https://www.uniprot.org/uniprotkb/P48729/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000113712","url":"https://platform.opentargets.org/target/ENSG00000113712/associations","note":"association with cancer (MONDO_0004992) 0.59;  (GraphQL API, CC0)"}],"hgnc":"HGNC:2451","ensembl":"ENSG00000113712","uniprot":"P48729","entrez":"1452","biology":"Casein kinases are operationally defined by their preferential utilisation of acidic proteins such as caseins as substrates. Phosphorylates a large number of proteins. Participates in Wnt signalling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. Location: Cytoplasm; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Chromosome, centromere, kinetochore; Nucleus speckle (UniProt). Locus 5q32 (HGNC).","whereFound":[],"targetClass":"kinase","prevalence":[]},"route":"/targets/csnk1a1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}