{"entity":{"id":"ctag1b","kind":"target","name":"CTAG1B","aka":["cancer/testis antigen 1B","Cancer/testis antigen 1","NY-ESO-1","LAGE2B","LAGE2A","ESO1","CT6.1","CTAG1"],"tldr":"CTAG1B (Cancer/testis antigen 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Multiple myeloma.","summary":"UniProt has no function text for P78358; HGNC names it \"cancer/testis antigen 1B\".\n\nCIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Letetresgene Autoleucel. In OnCo, 1 product record names it (Letetresgene autoleucel).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2491","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2491"},{"label":"UniProt P78358","url":"https://www.uniprot.org/uniprotkb/P78358/entry"},{"label":"NCBI Gene 1485","url":"https://www.ncbi.nlm.nih.gov/gene/1485"},{"label":"Ensembl ENSG00000184033","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000184033"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["multiple-myeloma"],"sections":[],"technologies":[],"targets":[],"drugs":["letetresgene-autoleucel"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct07174427"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate.","Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Myxoid Liposarcoma."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CTAG1B","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:2491","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2491","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P78358","url":"https://www.uniprot.org/uniprotkb/P78358/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene CTAG1B","url":"https://civicdb.org/features/1278","note":"2 evidence items, 0 assertions, 2 variants; diseases: Multiple Myeloma, Myxoid Liposarcoma (GraphQL API, CC0)"}],"hgnc":"HGNC:2491","ensembl":"ENSG00000184033","uniprot":"P78358","entrez":"1485","biology":"UniProt has no function text for P78358; HGNC names it \"cancer/testis antigen 1B\". Location: Cytoplasm (UniProt). Locus Xq28 (HGNC).","whereFound":["Multiple myeloma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/ctag1b/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"multiple-myeloma","kind":"cancer","name":"Multiple myeloma","route":"/cancers/multiple-myeloma/"}],"drug":[{"id":"letetresgene-autoleucel","kind":"drug","name":"Letetresgene autoleucel","route":"/drugs/letetresgene-autoleucel/"}],"trial":[{"id":"nct07174427","kind":"trial","name":"Multi-center Study of TBI-1301 (INN: Mipetresgene Autoleucel; Mip-cel) in Patients With NY-ESO-1 Positive Synovial Sarcoma","route":"/trials/nct07174427/"}]}}