{"entity":{"id":"ctnna1","kind":"target","name":"CTNNA1","aka":["catenin alpha 1","Catenin alpha-1","CAP102"],"tldr":"CTNNA1 (Catenin alpha-1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Gastric & gastro-oesophageal junction cancer, Colorectal cancer and Cervical cancer.","summary":"Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins.\n\nOpen Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes genetic literature 0.01, literature 0.92, genetic association 0.83, somatic mutation 0.43, animal model 0.60). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Cervical Adenocarcinoma, Colorectal Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2509","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2509"},{"label":"UniProt P35221","url":"https://www.uniprot.org/uniprotkb/P35221/entry"},{"label":"NCBI Gene 1495","url":"https://www.ncbi.nlm.nih.gov/gene/1495"},{"label":"Ensembl ENSG00000044115","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000044115"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["gastric","colorectal","cervical"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CTNNA1","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:2509","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2509","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P35221","url":"https://www.uniprot.org/uniprotkb/P35221/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000044115","url":"https://platform.opentargets.org/target/ENSG00000044115/associations","note":"association with cancer (MONDO_0004992) 0.68; per-cancer scores at or above 0.5: colorectal cancer 0.59, gastric cancer 0.63 (GraphQL API, CC0)"},{"label":"IntOGen CTNNA1","url":"https://www.intogen.org/search?gene=CTNNA1","note":"driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:2509","ensembl":"ENSG00000044115","uniprot":"P35221","entrez":"1495","biology":"Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Location: Cytoplasm, cytoskeleton; Cell junction, adherens junction; Cell membrane; Cell junction (UniProt). Locus 5q31.2 (HGNC).","whereFound":["Gastric & gastro-oesophageal junction cancer: Open Targets association 0.63 with gastric cancer (MONDO_0001056)","Colorectal cancer: Open Targets association 0.59 with colorectal cancer (MONDO_0005575); IntOGen driver in 1 cohort (COADREAD)","Cervical cancer: IntOGen driver in 1 cohort (CEAD)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/ctnna1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"cervical","kind":"cancer","name":"Cervical cancer","route":"/cancers/cervical/"},{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"}]}}