{"entity":{"id":"ctnnd2","kind":"target","name":"CTNND2","aka":["catenin delta 2","Catenin delta-2","NPRAP","GT24"],"tldr":"CTNND2 (Catenin delta-2) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Ovarian cancer, Pancreatic ductal adenocarcinoma and 3 more.","summary":"Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signalling. It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation.\n\nIntOGen calls it a driver in 7 cohorts (5 activating, 2 loss-of-function), covering Oesophageal Adenocarcinoma, Lung Adenocarcinoma, Lung Squamous Cell Carcinoma, Melanoma, Ovarian Epithelial Tumour, Pancreatic Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2516","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2516"},{"label":"UniProt Q9UQB3","url":"https://www.uniprot.org/uniprotkb/Q9UQB3/entry"},{"label":"NCBI Gene 1501","url":"https://www.ncbi.nlm.nih.gov/gene/1501"},{"label":"Ensembl ENSG00000169862","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000169862"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["esophageal","ovarian","pancreatic","nsclc","oesophageal-adenocarcinoma","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 5 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CTNND2","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:2516","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2516","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UQB3","url":"https://www.uniprot.org/uniprotkb/Q9UQB3/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen CTNND2","url":"https://www.intogen.org/search?gene=CTNND2","note":"driver in 7 cohorts (Act 5, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:2516","ensembl":"ENSG00000169862","uniprot":"Q9UQB3","entrez":"1501","biology":"Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses. Involved in the regulation of Wnt signalling. It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation. Functions as a transcriptional activator when bound to ZBTB33. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Location: Nucleus; Cell junction, adherens junction; Cell projection, dendrite; Perikaryon (UniProt). Locus 5p15.2 (HGNC).","whereFound":["Oesophageal cancer: IntOGen driver in 1 cohort (ESCA)","Ovarian cancer: IntOGen driver in 1 cohort (OVT)","Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)","Non-small-cell lung cancer: IntOGen driver in 3 cohorts (LUAD, LUSC)","Oesophageal and junctional adenocarcinoma: IntOGen driver in 1 cohort (ESCA)","Melanoma: IntOGen driver in 1 cohort (MEL)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/ctnnd2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"oesophageal-adenocarcinoma","kind":"cancer","name":"Oesophageal and junctional adenocarcinoma","route":"/cancers/oesophageal-adenocarcinoma/"},{"id":"esophageal","kind":"cancer","name":"Oesophageal cancer","route":"/cancers/esophageal/"},{"id":"ovarian","kind":"cancer","name":"Ovarian cancer","route":"/cancers/ovarian/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}]}}