{"entity":{"id":"ctph-03","kind":"drug","name":"CTPH-03","aka":[],"tldr":"CTPH-03 is an experimental drug designed to carry chemotherapy to cancer cells. Its published evidence is from laboratory and animal studies.","summary":"AACR 2026 abstract 4438 describes CTPH-03 using an MMAE-based dual-payload format. Evidence comprises cell assays, cell-derived xenografts, rodent and monkey pharmacokinetics, and preliminary animal toxicity. The abstract describes patient-derived xenograft and IND-enabling studies as preparation. Neither the second payload identity nor human efficacy or safety can be inferred from these findings.","status":"preclinical","asOf":"2026-10-06","links":[{"label":"Publisher abstract","url":"https://doi.org/10.1158/1538-7445.am2026-4438"}],"tags":["evidence:preclinical"],"related":[],"cancers":[],"sections":[],"technologies":["adc","dual-payload-adc"],"targets":["trop2"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"modality":"ADC","payload":"MMAE-based dual payload; second payload not disclosed in the cited abstract","mechanism":"TROP2-directed ADC carrying an MMAE-based dual-payload combination; the other payload is not identified by the public abstract.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/ctph-03/","neighbours":{"technology":[{"id":"adc","kind":"technology","name":"Antibody-drug conjugate (ADC)","route":"/technologies/adc/"},{"id":"dual-payload-adc","kind":"technology","name":"Dual-payload ADC","route":"/technologies/dual-payload-adc/"}],"target":[{"id":"trop2","kind":"target","name":"TROP2","route":"/targets/trop2/"}]}}