{"entity":{"id":"ctsh","kind":"target","name":"CTSH","aka":["cathepsin H","Pro-cathepsin H","ACC-4","ACC-5","ACC4","ACC5"],"tldr":"CTSH (Pro-cathepsin H) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Important for the overall degradation of proteins in lysosomes.\n\nOpen Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.93, animal model 0.81, genetic association 0.70).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2535","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2535"},{"label":"UniProt P09668","url":"https://www.uniprot.org/uniprotkb/P09668/entry"},{"label":"NCBI Gene 1512","url":"https://www.ncbi.nlm.nih.gov/gene/1512"},{"label":"Ensembl ENSG00000103811","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000103811"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CTSH","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:2535","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2535","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P09668","url":"https://www.uniprot.org/uniprotkb/P09668/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000103811","url":"https://platform.opentargets.org/target/ENSG00000103811/associations","note":"association with cancer (MONDO_0004992) 0.57;  (GraphQL API, CC0)"}],"hgnc":"HGNC:2535","ensembl":"ENSG00000103811","uniprot":"P09668","entrez":"1512","biology":"Important for the overall degradation of proteins in lysosomes. Location: Lysosome (UniProt). Locus 15q25.1 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/ctsh/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}