{"entity":{"id":"cux1","kind":"target","name":"CUX1","aka":["cut like homeobox 1","Homeobox protein cut-like 1","CDP1","Clox","CDP/Cut","CDP/Cux","Cux/CDP","GOLIM6","CUTL1"],"tldr":"CUX1 (Homeobox protein cut-like 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Leukaemia, Breast cancer and 5 more.","summary":"Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis.\n\nOpen Targets scores its association with cancer at 0.82 (direct and indirect evidence; datatypes affected pathway 0.95, literature 0.96, genetic association 0.67, somatic mutation 0.88, animal model 0.69). IntOGen calls it a driver in 7 cohorts (2 activating, 5 loss-of-function), covering Invasive Breast Carcinoma, Glioblastoma, Lung Adenocarcinoma, Lung Squamous Cell Carcinoma, Melanoma, Pancreatic Adenocarcinoma and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2557","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2557"},{"label":"UniProt P39880","url":"https://www.uniprot.org/uniprotkb/P39880/entry"},{"label":"NCBI Gene 1523","url":"https://www.ncbi.nlm.nih.gov/gene/1523"},{"label":"Ensembl ENSG00000257923","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000257923"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["skin-cancer","leukaemia","breast-cancer","non-hodgkin-lymphoma","pancreatic","thyroid","lung-cancer","myeloproliferative-neoplasms"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 5 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CUX1","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:2557","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2557","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P39880","url":"https://www.uniprot.org/uniprotkb/P39880/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000257923","url":"https://platform.opentargets.org/target/ENSG00000257923/associations","note":"association with cancer (MONDO_0004992) 0.82; per-cancer scores at or above 0.5: colorectal cancer 0.50, gastric cancer 0.50, melanoma 0.61, acute lymphoblastic leukaemia 0.57, non-Hodgkin lymphoma 0.58, skin cancer 0.67 (GraphQL API, CC0)"},{"label":"IntOGen CUX1","url":"https://www.intogen.org/search?gene=CUX1","note":"driver in 7 cohorts (Act 2, LoF 5); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:2557","ensembl":"ENSG00000257923","uniprot":"P39880","entrez":"1523","biology":"Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Location: Nucleus (UniProt). Locus 7q22.1 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.67 with skin cancer (MONDO_0002898)","Leukaemia: Open Targets association 0.66 with leukaemia (MONDO_0005059)","Breast cancer: Open Targets association 0.66 with breast cancer (MONDO_0007254); IntOGen driver in 1 cohort (BRCA)","Non-Hodgkin lymphoma: Open Targets association 0.58 with non-Hodgkin lymphoma (MONDO_0018908)","Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD)","Thyroid cancer: IntOGen driver in 1 cohort (WDTC)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/cux1/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"},{"id":"thyroid","kind":"cancer","name":"Thyroid cancer","route":"/cancers/thyroid/"}]}}