{"entity":{"id":"cxcl10","kind":"target","name":"CXCL10","aka":["C-X-C motif chemokine ligand 10","C-X-C motif chemokine 10","IFI10","IP-10","crg-2","mob-1","C7","gIP-10","INP10","SCYB10"],"tldr":"CXCL10 (C-X-C motif chemokine 10) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Osteosarcoma.","summary":"Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signalling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganisation.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:10637","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10637"},{"label":"UniProt P02778","url":"https://www.uniprot.org/uniprotkb/P02778/entry"},{"label":"NCBI Gene 3627","url":"https://www.ncbi.nlm.nih.gov/gene/3627"},{"label":"Ensembl ENSG00000169245","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000169245"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["osteosarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["cgas-sting"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CXCL10","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:10637","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10637","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P02778","url":"https://www.uniprot.org/uniprotkb/P02778/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene CXCL10","url":"https://civicdb.org/features/3017","note":"1 evidence items, 0 assertions, 1 variants; diseases: Osteosarcoma (GraphQL API, CC0)"}],"hgnc":"HGNC:10637","ensembl":"ENSG00000169245","uniprot":"P02778","entrez":"3627","biology":"Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signalling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganisation. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganisation. Location: Secreted (UniProt). Locus 4q21.1 (HGNC).","whereFound":["Osteosarcoma: CIViC evidence names this disease"],"targetClass":"other","prevalence":[]},"route":"/targets/cxcl10/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"osteosarcoma","kind":"cancer","name":"Osteosarcoma","route":"/cancers/osteosarcoma/"}],"pathway":[{"id":"cgas-sting","kind":"pathway","name":"cGAS-STING innate sensing","route":"/pathways/cgas-sting/"}]}}