{"entity":{"id":"cxcr3","kind":"target","name":"CXCR3","aka":[],"tldr":"CXCR3 is the receptor a killer T cell uses to find its way into a tumour. If the tumour is not making the signals it listens for, the T cells never arrive, which is one way a tumour stays cold.","summary":"CXCR3 binds the interferon-induced chemokines CXCL9, CXCL10 and CXCL11, and it is the receptor that steers effector T cells towards inflamed tissue. It is the mechanical link between the interferon-gamma signature and T cell infiltration: a tumour that does not produce those chemokines is not entered by the cells that could kill it, which is one of the described routes to immune exclusion and a cold tumour.","asOf":"2026-10-16","wikipedia":"https://en.wikipedia.org/wiki/CXCR3","links":[{"label":"HGNC:4540","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4540"}],"tags":["immune-marker"],"related":["cd8","interferon-gamma-signature"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["immune-exclusion","cold-vs-hot"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"symbol":"CXCR3","role":[],"sources":[],"specificitySources":[],"biology":"Chemokine receptor for CXCL9, CXCL10 and CXCL11; guides effector T cells towards interferon-driven inflammation.","whereFound":["Effector and effector memory T cells","Natural killer cells"],"targetClass":"surface-antigen","prevalence":[]},"route":"/targets/cxcr3/","neighbours":{"target":[{"id":"cd8","kind":"target","name":"CD8","route":"/targets/cd8/"}],"term":[{"id":"cold-vs-hot","kind":"term","name":"Hot vs cold tumours","route":"/terms/cold-vs-hot/"},{"id":"immune-exclusion","kind":"term","name":"Immune exclusion","route":"/terms/immune-exclusion/"},{"id":"interferon-gamma-signature","kind":"term","name":"Interferon-gamma gene signature (T-cell-inflamed signature)","route":"/terms/interferon-gamma-signature/"}]}}