{"entity":{"id":"cxcr5","kind":"target","name":"CXCR5","aka":[],"tldr":"CXCR5 is what draws immune cells into the follicles where B cells are trained. The same signal builds the lymph-node-like structures that sometimes form inside tumours and are linked to better outcomes.","summary":"CXCR5 binds CXCL13 and is the receptor that organises cells into B cell follicles, carried by B cells and by the follicular helper T cells that support them. Its relevance to cancer is through tertiary lymphoid structures, the organised immune aggregates that form within some tumours and are associated with response to checkpoint blockade; CXCL13 and CXCR5 are part of how those structures assemble.","asOf":"2026-10-16","wikipedia":"https://en.wikipedia.org/wiki/CXCR5","links":[{"label":"HGNC:1060","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1060"}],"tags":["immune-marker"],"related":["cd4","ccr6"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["tertiary-lymphoid-structures"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"symbol":"CXCR5","role":[],"sources":[],"specificitySources":[],"biology":"Receptor for CXCL13; directs cells into B cell follicles and germinal centres.","whereFound":["B cells","Follicular helper T cells"],"targetClass":"surface-antigen","prevalence":[]},"route":"/targets/cxcr5/","neighbours":{"target":[{"id":"ccr6","kind":"target","name":"CCR6","route":"/targets/ccr6/"},{"id":"cd4","kind":"target","name":"CD4","route":"/targets/cd4/"}],"term":[{"id":"tertiary-lymphoid-structures","kind":"term","name":"Tertiary lymphoid structures (TLS)","route":"/terms/tertiary-lymphoid-structures/"}]}}