{"entity":{"id":"cyclizine","kind":"drug","name":"Cyclizine","aka":[],"tldr":"Cyclizine is an anti-sickness tablet or injection widely used in the UK, including for sickness caused by opioid painkillers and by radiotherapy.","summary":"The UK SmPCs list prevention and treatment of nausea and vomiting from motion sickness, from narcotic analgesics and general anaesthetics after surgery, and \"vomiting associated with radiotherapy especially for breast cancer since Cyclizine does not elevate prolactin levels\". The Scottish Palliative Care Guidelines advise against prescribing a prokinetic such as metoclopramide together with an anticholinergic such as cyclizine, because the anticholinergic diminishes the prokinetic effect. It is not marketed as a prescription medicine in the US.","status":"approved","asOf":"2026-11-11","wikipedia":"https://en.wikipedia.org/wiki/Cyclizine","links":[{"label":"UK SmPC (emc): cyclizine 50 mg tablets","url":"https://www.medicines.org.uk/emc/product/4318/smpc"},{"label":"UK SmPC (emc): cyclizine 50 mg/ml injection","url":"https://www.medicines.org.uk/emc/product/100940/smpc"},{"label":"Scottish Palliative Care Guidelines: nausea and vomiting","url":"https://www.palliativecareguidelines.scot.nhs.uk/scottish-palliative-care-guidelines/symptoms/non-pain-symptoms/nausea-and-vomiting/"}],"tags":["supportive","generic","supportive-care-gaps-2026-11"],"related":["metoclopramide"],"cancers":["breast-cancer"],"sections":[],"technologies":["antiemetic-therapy"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"provenance":{"editedBy":"OnCo supportive care gap fill (DailyMed, openFDA, Drugs@FDA, emc SmPCs, NICE, ESMO, ASCO, MASCC, SITC, ASTCT, ITAC, Europe PMC)","editedOn":"2026-11-11"},"brand":"Valoid","modality":"Antihistamine antiemetic (H1 receptor antagonist)","supportive":true,"mechanism":"A histamine H1 receptor antagonist of the piperazine class with anticholinergic and antiemetic properties (UK SmPC 5.1).","approvals":[{"region":"UK","year":2001,"indication":"Prevention and treatment of nausea and vomiting: motion sickness, narcotic analgesics and general anaesthetics after surgery, and vomiting with radiotherapy, especially for breast cancer","note":"Year is the first authorisation of UK licence PL 20072/0241 (tablets) as printed in its SmPC, not the first approval of the medicine"}],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/cyclizine/","neighbours":{"drug":[{"id":"metoclopramide","kind":"drug","name":"Metoclopramide","route":"/drugs/metoclopramide/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}],"technology":[{"id":"antiemetic-therapy","kind":"technology","name":"Antiemetics for chemotherapy-induced nausea and vomiting","route":"/technologies/antiemetic-therapy/"}]}}