{"entity":{"id":"cyp11b1","kind":"target","name":"CYP11B1","aka":["cytochrome P450 family 11 subfamily B member 1","Cytochrome P450 11B1, mitochondrial","P450C11","CPN1","CYP11B"],"tldr":"CYP11B1 (Cytochrome P450 11B1, mitochondrial) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Renal cell carcinoma.","summary":"A cytochrome P450 monooxygenase mainly involved in the biosynthesis of adrenal corticoids. Catalyses a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones. Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19.\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.27, animal model 0.54, genetic association 0.00, clinical 0.83).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2591","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2591"},{"label":"UniProt P15538","url":"https://www.uniprot.org/uniprotkb/P15538/entry"},{"label":"NCBI Gene 1584","url":"https://www.ncbi.nlm.nih.gov/gene/1584"},{"label":"Ensembl ENSG00000160882","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000160882"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["rcc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.83. Evidence tier \"approved-drug\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CYP11B1","role":["drug-target"],"evidenceTier":"approved-drug","sources":[{"label":"HGNC HGNC:2591","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2591","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P15538","url":"https://www.uniprot.org/uniprotkb/P15538/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000160882","url":"https://platform.opentargets.org/target/ENSG00000160882/associations","note":"association with cancer (MONDO_0004992) 0.52; per-cancer scores at or above 0.5: renal cell carcinoma 0.52 (GraphQL API, CC0)"}],"hgnc":"HGNC:2591","ensembl":"ENSG00000160882","uniprot":"P15538","entrez":"1584","biology":"A cytochrome P450 monooxygenase mainly involved in the biosynthesis of adrenal corticoids. Catalyses a variety of reactions that are essential for many species, including detoxification, defense, and the formation of endogenous chemicals like steroid hormones. Steroid 11beta, 18- and 19-hydroxylase with preferred regioselectivity at 11beta, then 18, and lastly 19. Catalyses the hydroxylation of 11-deoxycortisol and 11-deoxycorticosterone (21-hydroxyprogesterone) at 11beta position, yielding cortisol or corticosterone, respectively, but cannot produce aldosterone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate for hydroxylation and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin). Location: Mitochondrion inner membrane (UniProt). Locus 8q24.3 (HGNC).","whereFound":["Renal cell carcinoma: Open Targets association 0.52 with renal cell carcinoma (MONDO_0005086)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/cyp11b1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"rcc","kind":"cancer","name":"Renal cell carcinoma","route":"/cancers/rcc/"}]}}