{"entity":{"id":"cyp1b1","kind":"target","name":"CYP1B1","aka":["cytochrome P450 family 1 subfamily B member 1","Cytochrome P450 1B1","CP1B","GLC3A"],"tldr":"CYP1B1 (Cytochrome P450 1B1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Skin cancer, Melanoma and Basal cell carcinoma.","summary":"A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--haemoprotein reductase). Exhibits catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2- and 4-hydroxy E1 and E2.\n\nOpen Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.98, animal model 0.68, genetic association 0.74).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2597","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2597"},{"label":"UniProt Q16678","url":"https://www.uniprot.org/uniprotkb/Q16678/entry"},{"label":"NCBI Gene 1545","url":"https://www.ncbi.nlm.nih.gov/gene/1545"},{"label":"Ensembl ENSG00000138061","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138061"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["skin-cancer","melanoma","basal-cell-carcinoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["chemical-carcinogenesis-receptor-activation"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CYP1B1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:2597","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2597","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q16678","url":"https://www.uniprot.org/uniprotkb/Q16678/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000138061","url":"https://platform.opentargets.org/target/ENSG00000138061/associations","note":"association with cancer (MONDO_0004992) 0.60; per-cancer scores at or above 0.5: melanoma 0.56, skin cancer 0.55, basal cell carcinoma 0.55 (GraphQL API, CC0)"}],"hgnc":"HGNC:2597","ensembl":"ENSG00000138061","uniprot":"Q16678","entrez":"1545","biology":"A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--haemoprotein reductase). Exhibits catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2- and 4-hydroxy E1 and E2. Displays a predominant hydroxylase activity toward E2 at the C-4 position. Metabolises testosterone and progesterone to B or D ring hydroxylated metabolites. May act as a major enzyme for all-trans retinoic acid biosynthesis in extrahepatic tissues. Location: Endoplasmic reticulum membrane; Microsome membrane; Mitochondrion (UniProt). Locus 2p22.2 (HGNC).","whereFound":["Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)","Melanoma: Open Targets association 0.56 with melanoma (MONDO_0005105)","Basal cell carcinoma: Open Targets association 0.55 with basal cell carcinoma (MONDO_0020804)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/cyp1b1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"basal-cell-carcinoma","kind":"cancer","name":"Basal cell carcinoma","route":"/cancers/basal-cell-carcinoma/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}],"pathway":[{"id":"chemical-carcinogenesis-receptor-activation","kind":"pathway","name":"Chemical carcinogenesis - receptor activation","route":"/pathways/chemical-carcinogenesis-receptor-activation/"}]}}