{"entity":{"id":"cyp2c8","kind":"target","name":"CYP2C8","aka":["cytochrome P450 family 2 subfamily C member 8","Cytochrome P450 2C8","CPC8"],"tldr":"CYP2C8 (Cytochrome P450 2C8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma, Melanoma and Pleural mesothelioma.","summary":"A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--haemoprotein reductase). Primarily catalyses the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond.\n\nIntOGen calls it a driver in 2 cohorts (2 activating, 0 loss-of-function), covering Melanoma, Pleural Mesothelioma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2622","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2622"},{"label":"UniProt P10632","url":"https://www.uniprot.org/uniprotkb/P10632/entry"},{"label":"NCBI Gene 1558","url":"https://www.ncbi.nlm.nih.gov/gene/1558"},{"label":"Ensembl ENSG00000138115","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000138115"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["mesothelioma","melanoma","pleural-mesothelioma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CYP2C8","role":["oncogene-driver"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:2622","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2622","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P10632","url":"https://www.uniprot.org/uniprotkb/P10632/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen CYP2C8","url":"https://www.intogen.org/search?gene=CYP2C8","note":"driver in 2 cohorts (Act 2, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:2622","ensembl":"ENSG00000138115","uniprot":"P10632","entrez":"1558","biology":"A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--haemoprotein reductase). Primarily catalyses the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond. Catalyses the hydroxylation of carbon-hydrogen bonds. Metabolises all trans-retinoic acid toward its 4-hydroxylated form. Displays 16-alpha hydroxylase activity toward oestrogen steroid hormones, 17beta-estradiol (E2) and estrone (E1). Location: Endoplasmic reticulum membrane; Microsome membrane (UniProt). Locus 10q23.33 (HGNC).","whereFound":["Mesothelioma: IntOGen driver in 1 cohort (PLMESO)","Melanoma: IntOGen driver in 1 cohort (MEL)","Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/cyp2c8/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"},{"id":"pleural-mesothelioma","kind":"cancer","name":"Pleural mesothelioma","route":"/cancers/pleural-mesothelioma/"}]}}