{"entity":{"id":"cyp2d6","kind":"target","name":"CYP2D6","aka":["cytochrome P450 family 2 subfamily D member 6 (gene/pseudogene)","Cytochrome P450 2D6","CPD6","P450-DB1","CYP2D","P450C2D","CYP2DL1","CYP2D7P2","CYP2D7BP","CYP2D8P2","CYP2D7AP"],"tldr":"CYP2D6 (Cytochrome P450 2D6) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.","summary":"A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--haemoprotein reductase). Catalyses the epoxidation of double bonds of polyunsaturated fatty acids (PUFA).\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2625","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2625"},{"label":"UniProt P10635","url":"https://www.uniprot.org/uniprotkb/P10635/entry"},{"label":"NCBI Gene 1565","url":"https://www.ncbi.nlm.nih.gov/gene/1565"},{"label":"Ensembl ENSG00000100197","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100197"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct03351062"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CYP2D6","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:2625","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2625","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P10635","url":"https://www.uniprot.org/uniprotkb/P10635/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene CYP2D6","url":"https://civicdb.org/features/1342","note":"1 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer (GraphQL API, CC0)"}],"hgnc":"HGNC:2625","ensembl":"ENSG00000100197","uniprot":"P10635","entrez":"1565","biology":"A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--haemoprotein reductase). Catalyses the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolises endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signalling. Catalyses the hydroxylation of carbon-hydrogen bonds. Metabolises cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. Location: Endoplasmic reticulum membrane; Microsome membrane (UniProt). Locus 22q13.2 (HGNC).","whereFound":["Breast cancer: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/cyp2d6/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"}],"trial":[{"id":"nct03351062","kind":"trial","name":"Efficacy of Tamoxifen Versus Toremifene in CYP2D6 IM/PM of Premenopausal Patients With ER-positive Early Breast Cancer","route":"/trials/nct03351062/"}]}}