{"entity":{"id":"cyto-pv","kind":"trial","name":"CYTO-PV","aka":[],"tldr":"CYTO-PV settled the most basic question in PV: keeping the haematocrit under 45 percent gives far fewer serious clots and cardiovascular deaths than a looser target.","summary":"CYTO-PV randomised 365 adults with polycythaemia vera to a haematocrit target below 45 percent or between 45 and 50 percent, achieved with phlebotomy and hydroxyurea. After a median of 31 months the primary endpoint of cardiovascular death or major thrombosis occurred in 2.7 percent of the low-target group and 9.8 percent of the high-target group (Marchioli and colleagues, New England Journal of Medicine 2013). The result made 45 percent the universal target.","status":"positive","asOf":"2026-09-16","links":[{"label":"ClinicalTrials.gov NCT01645124","url":"https://clinicaltrials.gov/study/NCT01645124"},{"label":"NEJM 2013","url":"https://www.nejm.org/doi/full/10.1056/NEJMoa1208500"}],"tags":["polycythaemia-vera","mpn"],"related":[],"cancers":["polycythaemia-vera","myeloproliferative-neoplasms"],"sections":[],"technologies":[],"targets":[],"drugs":["hydroxyurea"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"nct":"NCT01645124","phase":"3","setting":"Polycythaemia vera: haematocrit target below 45 percent versus 45 to 50 percent","sponsor":"GIMEMA (Gruppo Italiano Malattie Ematologiche dell'Adulto)","result":"Cardiovascular death or major thrombosis 2.7% vs 9.8% (hazard ratio 3.91 for the higher target).","yearReported":2013,"enrolled":365,"outcomes":[{"endpoint":"Cardiovascular death or major thrombosis","primary":true,"unit":"%","arms":[{"name":"Haematocrit below 45%","n":182,"value":2.7},{"name":"Haematocrit 45 to 50%","n":183,"value":9.8}]}]},"route":"/trials/cyto-pv/","neighbours":{"cancer":[{"id":"myeloproliferative-neoplasms","kind":"cancer","name":"Myeloproliferative neoplasms (PV, ET, myelofibrosis)","route":"/cancers/myeloproliferative-neoplasms/"},{"id":"polycythaemia-vera","kind":"cancer","name":"Polycythaemia vera (PV)","route":"/cancers/polycythaemia-vera/"}],"drug":[{"id":"hydroxyurea","kind":"drug","name":"Hydroxyurea (hydroxycarbamide)","route":"/drugs/hydroxyurea/"}],"term":[{"id":"haematocrit","kind":"term","name":"Haematocrit","route":"/terms/haematocrit/"},{"id":"phlebotomy","kind":"term","name":"Phlebotomy (venesection)","route":"/terms/phlebotomy/"}]}}