{"entity":{"id":"dahanca-5","kind":"trial","name":"DAHANCA 5","aka":[],"tldr":"DAHANCA 5 is the trial that made hypoxic sensitisation real in the clinic: nimorazole with radiotherapy improved control of head and neck cancer, and Denmark has used it as standard ever since.","summary":"DAHANCA 5 randomised 422 patients with carcinoma of the supraglottic larynx or pharynx to nimorazole or placebo during conventional radiotherapy. Five-year locoregional control was 49 percent with nimorazole and 33 percent with placebo, with a survival advantage in the pharynx subgroup and minimal added toxicity (Overgaard and colleagues, Radiotherapy and Oncology 1998). A later analysis showed the benefit was confined to tumours with a hypoxic gene signature, and a European confirmatory trial (EORTC 1219) followed.","status":"positive","asOf":"2026-09-16","links":[{"label":"Radiotherapy and Oncology 1998","url":"https://doi.org/10.1016/S0167-8140(97)00220-X"}],"tags":["radiation-wave2"],"related":[],"cancers":["head-and-neck"],"sections":[],"technologies":["radiosensitisers","tumour-hypoxia-modification"],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["tumour-hypoxia"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"phase":"3","setting":"Supraglottic larynx and pharynx cancer treated with radiotherapy: the hypoxic radiosensitiser nimorazole versus placebo","sponsor":"Danish Head and Neck Cancer Group","result":"5-year locoregional control 49% (nimorazole) vs 33% (placebo).","yearReported":1998,"enrolled":422,"outcomes":[{"endpoint":"Locoregional control at 5 years","primary":true,"unit":"%","arms":[{"name":"Nimorazole plus radiotherapy","n":219,"value":49},{"name":"Placebo plus radiotherapy","n":203,"value":33}]}]},"route":"/trials/dahanca-5/","neighbours":{"cancer":[{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"}],"technology":[{"id":"radiosensitisers","kind":"technology","name":"Radiosensitisers","route":"/technologies/radiosensitisers/"},{"id":"tumour-hypoxia-modification","kind":"technology","name":"Tumour hypoxia: imaging and modification","route":"/technologies/tumour-hypoxia-modification/"}],"term":[{"id":"tumour-hypoxia","kind":"term","name":"Tumour hypoxia","route":"/terms/tumour-hypoxia/"}],"drug":[{"id":"nimorazole","kind":"drug","name":"Nimorazole","route":"/drugs/nimorazole/"}]}}