{"entity":{"id":"darren-hargrave","kind":"person","name":"Darren R. Hargrave","aka":[],"tldr":"London paediatric neuro-oncologist who led the trial showing that dabrafenib and trametinib work in children with BRAF V600-mutant high-grade glioma.","summary":"Darren Hargrave is a paediatric neuro-oncologist at Great Ormond Street Hospital and a leader of European paediatric drug-development consortia. He was first author of the 2023 Journal of Clinical Oncology report of the phase 2 trial in which dabrafenib plus trametinib produced responses in relapsed or refractory BRAF V600-mutant paediatric high-grade glioma, and a senior investigator on the trial that established the same combination for paediatric low-grade glioma.","asOf":"2026-09-18","links":[],"tags":["paediatric","brain","targeted-therapy","trialist"],"related":[],"cancers":["paediatric-high-grade-glioma","childhood-cancers"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["great-ormond-street"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":["paper-hargrave-dabrafenib-trametinib-paediatric-hgg-jco-2023"],"journals":[],"dependsOn":[],"notes":[],"role":"Paediatric neuro-oncologist, Great Ormond Street Hospital and UCL Great Ormond Street Institute of Child Health","institutionId":"great-ormond-street","specialisms":["Paediatric glioma","BRAF-directed therapy","Paediatric drug development"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Hargrave%5BAuthor%5D"}],"papers":[],"orcid":"0000-0001-8219-9807"},"route":"/people/darren-hargrave/","neighbours":{"cancer":[{"id":"childhood-cancers","kind":"cancer","name":"Childhood cancers (all types)","route":"/cancers/childhood-cancers/"},{"id":"paediatric-high-grade-glioma","kind":"cancer","name":"Paediatric high-grade glioma (excluding diffuse midline glioma)","route":"/cancers/paediatric-high-grade-glioma/"}],"institution":[{"id":"great-ormond-street","kind":"institution","name":"Great Ormond Street Hospital for Children","route":"/institutions/great-ormond-street/"}],"paper":[{"id":"paper-hargrave-dabrafenib-trametinib-paediatric-hgg-jco-2023","kind":"paper","name":"Dabrafenib plus trametinib in relapsed or refractory BRAF V600-mutant paediatric high-grade glioma","route":"/key-papers/paper-hargrave-dabrafenib-trametinib-paediatric-hgg-jco-2023/"}]}}