{"entity":{"id":"david-sebag-montefiore","kind":"person","name":"David Sebag-Montefiore","aka":[],"tldr":"The Leeds clinical oncologist who led CR07, the trial that made short-course radiotherapy before surgery the standard for rectal cancer, and who now works on preserving the rectum instead of removing it.","summary":"David Sebag-Montefiore is an academic clinical oncologist at the University of Leeds and an honorary clinical oncologist at Leeds Cancer Centre, Leeds Teaching Hospitals NHS Trust. He leads the Leeds Radiotherapy Research Group and is a clinical director of the Leeds Clinical Trials Research Unit; he was awarded the Audrey and Stanley Burton Chair of Clinical Oncology in 2012. He was first author of MRC CR07, which showed that short-course preoperative radiotherapy cut local recurrence by 61 percent against surgery with selective postoperative chemoradiotherapy, and is second author of the STAR-TREC 12-month results, the first randomised comparison of two radiotherapy schedules for organ preservation in rectal cancer.","asOf":"2026-09-24","links":[{"label":"University of Leeds staff page","url":"https://medicinehealth.leeds.ac.uk/medicine/staff/745/professor-david-sebag-montefiore"}],"tags":["colorectal","trialist","uk","radiotherapy"],"related":["matt-seymour","dion-morton"],"cancers":["colorectal","rectal-cancer"],"sections":["radiation"],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["leeds-cancer-centre"],"pathways":[],"terms":["radiotherapy"],"trials":["cr07","star-trec"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Professor of Clinical Oncology (Audrey and Stanley Burton Chair), University of Leeds; Clinical Director, Leeds Clinical Trials Research Unit","institutionId":"leeds-cancer-centre","specialisms":["Rectal cancer radiotherapy","Organ preservation","Randomised radiotherapy trials"],"profiles":[{"label":"University of Leeds staff page","url":"https://medicinehealth.leeds.ac.uk/medicine/staff/745/professor-david-sebag-montefiore"}],"papers":[{"title":"Preoperative radiotherapy versus selective postoperative chemoradiotherapy in patients with rectal cancer (MRC CR07 and NCIC-CTG C016): a multicentre, randomised trial","journal":"Lancet","year":2009,"doi":"10.1016/S0140-6736(09)60484-0"},{"title":"Chemoradiotherapy versus short-course radiotherapy for response-adapted organ preservation in early-stage and intermediate-stage rectal cancer (STAR-TREC): 12-month results","journal":"Lancet Oncology","year":2026,"doi":"10.1016/S1470-2045(26)00228-7"}]},"route":"/people/david-sebag-montefiore/","neighbours":{"person":[{"id":"dion-morton","kind":"person","name":"Dion Morton","route":"/people/dion-morton/"},{"id":"matt-seymour","kind":"person","name":"Matt Seymour","route":"/people/matt-seymour/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"rectal-cancer","kind":"cancer","name":"Rectal cancer","route":"/cancers/rectal-cancer/"}],"section":[{"id":"radiation","kind":"section","name":"Radiation Therapy","route":"/fronts/radiation/"}],"institution":[{"id":"leeds-cancer-centre","kind":"institution","name":"Leeds Cancer Centre, St James's University Hospital","route":"/institutions/leeds-cancer-centre/"}],"term":[{"id":"radiotherapy","kind":"term","name":"Radiotherapy","route":"/terms/radiotherapy/"}],"trial":[{"id":"cr07","kind":"trial","name":"MRC CR07","route":"/trials/cr07/"},{"id":"star-trec","kind":"trial","name":"STAR-TREC","route":"/trials/star-trec/"}]}}