{"entity":{"id":"daxx","kind":"target","name":"DAXX","aka":["death domain associated protein","Death domain-associated protein 6","DAP6"],"tldr":"DAXX (Death domain-associated protein 6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Neuroendocrine tumours, Adrenocortical carcinoma, Pancreatic ductal adenocarcinoma and 2 more.","summary":"Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively.\n\nOpen Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.61, genetic association 0.00, somatic mutation 0.91). IntOGen calls it a driver in 3 cohorts (0 activating, 3 loss-of-function), covering Adrenocortical Carcinoma, Pancreas, Pancreatic Neuroendocrine Tumour.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2681","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2681"},{"label":"UniProt Q9UER7","url":"https://www.uniprot.org/uniprotkb/Q9UER7/entry"},{"label":"NCBI Gene 1616","url":"https://www.ncbi.nlm.nih.gov/gene/1616"},{"label":"Ensembl ENSG00000204209","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000204209"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["neuroendocrine","adrenocortical","pancreatic","skin-cancer","melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":["telomere-maintenance"],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 3 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DAXX","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:2681","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2681","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9UER7","url":"https://www.uniprot.org/uniprotkb/Q9UER7/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000204209","url":"https://platform.opentargets.org/target/ENSG00000204209/associations","note":"association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: melanoma 0.55, neuroendocrine neoplasm 0.61, skin cancer 0.55 (GraphQL API, CC0)"},{"label":"IntOGen DAXX","url":"https://www.intogen.org/search?gene=DAXX","note":"driver in 3 cohorts (Act 0, LoF 3); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:2681","ensembl":"ENSG00000204209","uniprot":"Q9UER7","entrez":"1616","biology":"Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Location: Cytoplasm; Nucleus, nucleoplasm; Nucleus, PML body; Nucleus, nucleolus (UniProt). Locus 6p21.32 (HGNC).","whereFound":["Neuroendocrine tumours: Open Targets association 0.61 with neuroendocrine neoplasm (MONDO_0019496); IntOGen driver in 1 cohort (PANET)","Adrenocortical carcinoma: IntOGen driver in 1 cohort (ACC)","Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PANCREAS)","Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)","Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/daxx/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"adrenocortical","kind":"cancer","name":"Adrenocortical carcinoma","route":"/cancers/adrenocortical/"},{"id":"melanoma","kind":"cancer","name":"Melanoma","route":"/cancers/melanoma/"},{"id":"neuroendocrine","kind":"cancer","name":"Neuroendocrine tumours","route":"/cancers/neuroendocrine/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}],"pathway":[{"id":"telomere-maintenance","kind":"pathway","name":"Telomere maintenance & replicative immortality","route":"/pathways/telomere-maintenance/"}]}}