{"entity":{"id":"db-1305","kind":"drug","name":"DB-1305 / BNT325","aka":[],"tldr":"DB-1305 / BNT325 is an experimental antibody-drug conjugate being studied in people with advanced cancer. Its benefit and safety are still being evaluated.","summary":"SABCS 2025 abstract PS5-02-29 reports 26 previously treated metastatic TNBC patients at the March 31, 2025 cutoff. Prior sacituzumab govitecan was excluded. Median follow-up was 9.3 months; grade 3 or higher treatment-related adverse events occurred in 9/26 patients (34.6%) and one discontinued for anemia. The deposited abstract does not provide its referenced efficacy table, so a response rate is not inferred. This uncontrolled cohort cannot rank DB-1305 against approved ADCs.","status":"phase-1","asOf":"2026-10-06","links":[{"label":"Publisher abstract","url":"https://doi.org/10.1158/1557-3265.sabcs25-ps5-02-29"},{"label":"ClinicalTrials.gov NCT05438329","url":"https://clinicaltrials.gov/study/NCT05438329"}],"tags":[],"related":[],"cancers":[],"sections":[],"technologies":["adc"],"targets":["trop2"],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":["nct05438329","nct06953089"],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"modality":"ADC","payload":"TOP1 inhibitor","mechanism":"TROP2-directed antibody-drug conjugate with a cleavable linker and a topoisomerase I inhibitor.","approvals":[],"mechanismSteps":[],"toxicity":[],"access":[],"regulatoryEvents":[]},"route":"/drugs/db-1305/","neighbours":{"technology":[{"id":"adc","kind":"technology","name":"Antibody-drug conjugate (ADC)","route":"/technologies/adc/"}],"target":[{"id":"trop2","kind":"target","name":"TROP2","route":"/targets/trop2/"}],"trial":[{"id":"nct06953089","kind":"trial","name":"DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors","route":"/trials/nct06953089/"},{"id":"nct05438329","kind":"trial","name":"First-in-human Study of DB-1305/BNT325 for Advanced/Metastatic Solid Tumors","route":"/trials/nct05438329/"}]}}