{"entity":{"id":"dcaf12l2","kind":"target","name":"DCAF12L2","aka":["DDB1 and CUL4 associated factor 12 like 2","DDB1- and CUL4-associated factor 12-like protein 2","WDR40C"],"tldr":"DCAF12L2 (DDB1- and CUL4-associated factor 12-like protein 2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer, Prostate cancer, Glioma & glioblastoma and 1 more.","summary":"UniProt has no function text for Q5VW00; HGNC names it \"DDB1 and CUL4 associated factor 12 like 2\".\n\nIntOGen calls it a driver in 4 cohorts (3 activating, 1 loss-of-function), covering Colon Adenocarcinoma, Glioblastoma Multiforme, Lung Adenocarcinoma, Prostate Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:32950","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:32950"},{"label":"UniProt Q5VW00","url":"https://www.uniprot.org/uniprotkb/Q5VW00/entry"},{"label":"NCBI Gene 340578","url":"https://www.ncbi.nlm.nih.gov/gene/340578"},{"label":"Ensembl ENSG00000198354","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198354"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["colorectal","prostate","glioblastoma","nsclc"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DCAF12L2","role":["oncogene-driver","tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:32950","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:32950","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q5VW00","url":"https://www.uniprot.org/uniprotkb/Q5VW00/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen DCAF12L2","url":"https://www.intogen.org/search?gene=DCAF12L2","note":"driver in 4 cohorts (Act 3, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:32950","ensembl":"ENSG00000198354","uniprot":"Q5VW00","entrez":"340578","biology":"UniProt has no function text for Q5VW00; HGNC names it \"DDB1 and CUL4 associated factor 12 like 2\". Locus Xq25 (HGNC).","whereFound":["Colorectal cancer: IntOGen driver in 1 cohort (COAD)","Prostate cancer: IntOGen driver in 1 cohort (PRAD)","Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM)","Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUAD)"],"targetClass":"oncogene","prevalence":[]},"route":"/targets/dcaf12l2/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"},{"id":"nsclc","kind":"cancer","name":"Non-small-cell lung cancer","route":"/cancers/nsclc/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}]}}