{"entity":{"id":"dclk1","kind":"target","name":"DCLK1","aka":["doublecortin like kinase 1","DCAMKL1","DCLK"],"tldr":"DCLK1 is a kinase gene from neuronal development that also marks a rare stem-like cell population in the gut, studied as a colorectal and pancreatic cancer stem-cell marker.","summary":"UniProt describes DCLK1 as a probable kinase of neuronal migration expressed in the adult brain and, at lower levels, in the gut and other organs. In cancer research it is followed as a marker of tuft-like intestinal stem cells implicated in colorectal and pancreatic tumour initiation, and its transcript and protein levels track each other closely in proteogenomic data.","asOf":"2026-09-24","links":[{"label":"HGNC HGNC:2700","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2700"},{"label":"UniProt O15075","url":"https://www.uniprot.org/uniprotkb/O15075/entry"}],"tags":["cansim-terms"],"related":[],"cancers":["colorectal","pancreatic"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["co-amplification","cancer-ai-vocabulary","mrna-protein-concordance"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Named in the CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme."],"provenance":{"editedBy":"OnCo CanSim terms wave (HGNC REST, UniProt REST)","editedOn":"2026-09-24","note":"CanSim terms map 1.0.0 (docs/onco/terms.json, generated 2026-09-24), CC BY 4.0, attribution: CanSim project, an open, public-data-first cancer foundation-model programme"},"symbol":"DCLK1","role":["biomarker"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:2700","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2700","note":"approved symbol, name, aliases, locus and cross-references (REST API, 2026-09-24)"},{"label":"UniProt O15075","url":"https://www.uniprot.org/uniprotkb/O15075/entry","note":"protein name, function and tissue specificity text (REST API, 2026-09-24)"}],"specificitySources":[],"hgnc":"HGNC:2700","ensembl":"ENSG00000133083","uniprot":"O15075","entrez":"9201","biology":"Probable kinase in a calcium-signalling pathway controlling neuronal migration; in adults expressed in brain and detectable in heart, liver, spleen, prostate, ovary, small intestine and colon (UniProt O15075).","whereFound":["Locus 13q13.3 (HGNC)."],"targetClass":"kinase","prevalence":[]},"route":"/targets/dclk1/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}],"term":[{"id":"cancer-ai-vocabulary","kind":"term","name":"Cancer AI vocabulary (CanSim terms map)","route":"/terms/cancer-ai-vocabulary/"},{"id":"co-amplification","kind":"term","name":"Co-amplification and the 17q12 HER2 amplicon","route":"/terms/co-amplification/"},{"id":"mrna-protein-concordance","kind":"term","name":"mRNA to protein concordance","route":"/terms/mrna-protein-concordance/"}]}}