{"entity":{"id":"dctn1","kind":"target","name":"DCTN1","aka":["dynactin subunit 1","Dynactin subunit 1"],"tldr":"DCTN1 (Dynactin subunit 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.25, affected pathway 0.89, genetic association 0.00, somatic mutation 0.50).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2711","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2711"},{"label":"UniProt Q14203","url":"https://www.uniprot.org/uniprotkb/Q14203/entry"},{"label":"NCBI Gene 1639","url":"https://www.ncbi.nlm.nih.gov/gene/1639"},{"label":"Ensembl ENSG00000204843","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000204843"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DCTN1","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:2711","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2711","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q14203","url":"https://www.uniprot.org/uniprotkb/Q14203/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000204843","url":"https://platform.opentargets.org/target/ENSG00000204843/associations","note":"association with cancer (MONDO_0004992) 0.62;  (GraphQL API, CC0)"}],"hgnc":"HGNC:2711","ensembl":"ENSG00000204843","uniprot":"Q14203","entrez":"1639","biology":"Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerisation and by inhibiting microtubule catastrophe in neurons. Location: Cytoplasm; Cytoplasm, cytoskeleton; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole (UniProt). Locus 2p13.1 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/dctn1/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}