{"entity":{"id":"ddit3","kind":"target","name":"DDIT3","aka":["DNA damage inducible transcript 3","DDIT3 upstream open reading frame protein","CHOP10","GADD153"],"tldr":"DDIT3 (DDIT3 upstream open reading frame protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas and Liposarcoma.","summary":"Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP.\n\nOpen Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.97, genetic literature 0.30).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2726","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2726"},{"label":"UniProt P0DPQ6","url":"https://www.uniprot.org/uniprotkb/P0DPQ6/entry"},{"label":"NCBI Gene 1649","url":"https://www.ncbi.nlm.nih.gov/gene/1649"},{"label":"Ensembl ENSG00000175197","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000175197"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["sarcoma","liposarcoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DDIT3","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:2726","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2726","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P0DPQ6","url":"https://www.uniprot.org/uniprotkb/P0DPQ6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000175197","url":"https://platform.opentargets.org/target/ENSG00000175197/associations","note":"association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: sarcoma 0.63, liposarcoma 0.60 (GraphQL API, CC0)"}],"hgnc":"HGNC:2726","ensembl":"ENSG00000175197","uniprot":"P0DPQ6","entrez":"1649","biology":"Product of the upstream open reading frame (uORF) of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP. Location: Nucleus; Cytoplasm (UniProt). Locus 12q13.3 (HGNC).","whereFound":["Sarcomas: Open Targets association 0.63 with sarcoma (MONDO_0005089)","Liposarcoma: Open Targets association 0.60 with liposarcoma (MONDO_0005060)"],"targetClass":"other","prevalence":[]},"route":"/targets/ddit3/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"liposarcoma","kind":"cancer","name":"Liposarcoma","route":"/cancers/liposarcoma/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}