{"entity":{"id":"ddx10","kind":"target","name":"DDX10","aka":["DEAD-box helicase 10","Probable ATP-dependent RNA helicase DDX10","HRH-J8","Dbp4"],"tldr":"DDX10 (Probable ATP-dependent RNA helicase DDX10) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer and Skin cancer.","summary":"Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilising its protein level. Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression.\n\nOpen Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.87, animal model 0.31, genetic association 0.04, somatic mutation 0.98).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2735","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2735"},{"label":"UniProt Q13206","url":"https://www.uniprot.org/uniprotkb/Q13206/entry"},{"label":"NCBI Gene 1662","url":"https://www.ncbi.nlm.nih.gov/gene/1662"},{"label":"Ensembl ENSG00000178105","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000178105"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer","skin-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DDX10","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:2735","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2735","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q13206","url":"https://www.uniprot.org/uniprotkb/Q13206/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000178105","url":"https://platform.opentargets.org/target/ENSG00000178105/associations","note":"association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: skin cancer 0.51, breast cancer 0.54 (GraphQL API, CC0)"}],"hgnc":"HGNC:2735","ensembl":"ENSG00000178105","uniprot":"Q13206","entrez":"1662","biology":"Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilising its protein level. Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression. Location: Cytoplasm; Nucleus; Nucleus, nucleolus (UniProt). Locus 11q22.3 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)","Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/ddx10/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}