{"entity":{"id":"ddx3x","kind":"target","name":"DDX3X","aka":["DEAD-box helicase 3 X-linked","ATP-dependent RNA helicase DDX3X","HLP2","DDX14","CAP-Rf","DDX3"],"tldr":"DDX3X (ATP-dependent RNA helicase DDX3X) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Leukaemia, Breast cancer and 5 more.","summary":"Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 2 variants. Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.28, genetic association 0.00, somatic mutation 0.85). IntOGen calls it a driver in 23 cohorts (14 activating, 9 loss-of-function), covering Burkitt Lymphoma, Invasive Breast Carcinoma, Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma, Diffuse Large B-Cell Lymphoma, NOS, Head and Neck Squamous Cell Carcinoma, Lymphoid Neoplasm and others.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2745","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2745"},{"label":"UniProt O00571","url":"https://www.uniprot.org/uniprotkb/O00571/entry"},{"label":"NCBI Gene 1654","url":"https://www.ncbi.nlm.nih.gov/gene/1654"},{"label":"Ensembl ENSG00000215301","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000215301"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets","intogen"],"cancers":["non-hodgkin-lymphoma","leukaemia","breast-cancer","mesothelioma","head-and-neck","skin-cancer","lung-cancer","medulloblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 14 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 9 cohorts; CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DDX3X","role":["oncogene-driver","tumour-suppressor","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:2745","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2745","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt O00571","url":"https://www.uniprot.org/uniprotkb/O00571/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene DDX3X","url":"https://civicdb.org/features/1417","note":"2 evidence items, 0 assertions, 2 variants; diseases: Diffuse Large B-cell Lymphoma, Burkitt Lymphoma (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000215301","url":"https://platform.opentargets.org/target/ENSG00000215301/associations","note":"association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: melanoma 0.64, acute lymphoblastic leukaemia 0.60, B-cell chronic lymphocytic leukaemia 0.50, non-Hodgkin lymphoma 0.73, skin cancer 0.55, medulloblastoma 0.69 (GraphQL API, CC0)"},{"label":"IntOGen DDX3X","url":"https://www.intogen.org/search?gene=DDX3X","note":"driver in 23 cohorts (Act 14, LoF 9); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:2745","ensembl":"ENSG00000215301","uniprot":"O00571","entrez":"1654","biology":"Multifunctional ATP-dependent RNA helicase. The ATPase activity can be stimulated by various ribo-and deoxynucleic acids indicative for a relaxed substrate specificity. In vitro can unwind partially double-stranded DNA with a preference for 5'-single-stranded DNA overhangs. Binds RNA G-quadruplex (rG4s) structures, including those located in the 5'-UTR of NRAS mRNA. Involved in many cellular processes, which do not necessarily require its ATPase/helicase catalytic activities. Involved in transcription regulation. Location: Cell membrane; Nucleus; Cytoplasm; Cytoplasm, Stress granule (UniProt). Locus Xp11.4 (HGNC).","whereFound":["Non-Hodgkin lymphoma: Open Targets association 0.73 with non-Hodgkin lymphoma (MONDO_0018908); IntOGen driver in 3 cohorts (LNM, MLYM, NHL)","Leukaemia: Open Targets association 0.62 with leukaemia (MONDO_0005059)","Breast cancer: IntOGen driver in 2 cohorts (BRCA)","Mesothelioma: IntOGen driver in 2 cohorts (PLMESO)","Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC)","Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/ddx3x/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"head-and-neck","kind":"cancer","name":"Head and neck squamous cell carcinoma","route":"/cancers/head-and-neck/"},{"id":"leukaemia","kind":"cancer","name":"Leukaemia (all types)","route":"/cancers/leukaemia/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"medulloblastoma","kind":"cancer","name":"Medulloblastoma","route":"/cancers/medulloblastoma/"},{"id":"mesothelioma","kind":"cancer","name":"Mesothelioma","route":"/cancers/mesothelioma/"},{"id":"non-hodgkin-lymphoma","kind":"cancer","name":"Non-Hodgkin lymphoma (all types)","route":"/cancers/non-hodgkin-lymphoma/"},{"id":"skin-cancer","kind":"cancer","name":"Skin cancer (all types)","route":"/cancers/skin-cancer/"}]}}