{"entity":{"id":"ddx43","kind":"target","name":"DDX43","aka":["DEAD-box helicase 43","Probable ATP-dependent RNA helicase DDX43","DKFZp434H2114","CT13"],"tldr":"DDX43 (Probable ATP-dependent RNA helicase DDX43) is an enzyme. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Uveal melanoma.","summary":"UniProt has no function text for Q9NXZ2; HGNC names it \"DEAD-box helicase 43\".\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Trametinib, Mirdametinib and Selumetinib.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18677","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18677"},{"label":"UniProt Q9NXZ2","url":"https://www.uniprot.org/uniprotkb/Q9NXZ2/entry"},{"label":"NCBI Gene 55510","url":"https://www.ncbi.nlm.nih.gov/gene/55510"},{"label":"Ensembl ENSG00000080007","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000080007"}],"tags":["cancer-genes-wave"],"related":["civic"],"cancers":["uveal-melanoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 3 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DDX43","role":["drug-target","biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:18677","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18677","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9NXZ2","url":"https://www.uniprot.org/uniprotkb/Q9NXZ2/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene DDX43","url":"https://civicdb.org/features/13005","note":"1 evidence items, 0 assertions, 1 variants; diseases: Uveal Melanoma (GraphQL API, CC0)"}],"hgnc":"HGNC:18677","ensembl":"ENSG00000080007","uniprot":"Q9NXZ2","entrez":"55510","biology":"UniProt has no function text for Q9NXZ2; HGNC names it \"DEAD-box helicase 43\". Locus 6q13 (HGNC).","whereFound":["Uveal melanoma: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/ddx43/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"}],"cancer":[{"id":"uveal-melanoma","kind":"cancer","name":"Uveal melanoma","route":"/cancers/uveal-melanoma/"}]}}