{"entity":{"id":"ddx6","kind":"target","name":"DDX6","aka":["DEAD-box helicase 6","Probable ATP-dependent RNA helicase DDX6","Rck/p54","HLR2"],"tldr":"DDX6 (Probable ATP-dependent RNA helicase DDX6) is an enzyme. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Sarcomas, Lung cancer, Leiomyosarcoma and 1 more.","summary":"Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping.\n\nOpen Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.87, genetic association 0.10, somatic mutation 0.83). IntOGen calls it a driver in 2 cohorts (1 activating, 1 loss-of-function), covering Leiomyosarcoma, Medulloblastoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2747","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2747"},{"label":"UniProt P26196","url":"https://www.uniprot.org/uniprotkb/P26196/entry"},{"label":"NCBI Gene 1656","url":"https://www.ncbi.nlm.nih.gov/gene/1656"},{"label":"Ensembl ENSG00000110367","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000110367"}],"tags":["cancer-genes-wave"],"related":["open-targets","intogen"],"cancers":["sarcoma","lung-cancer","leiomyosarcoma","medulloblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DDX6","role":["oncogene-driver","tumour-suppressor","fusion-partner"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:2747","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2747","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P26196","url":"https://www.uniprot.org/uniprotkb/P26196/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000110367","url":"https://platform.opentargets.org/target/ENSG00000110367/associations","note":"association with cancer (MONDO_0004992) 0.65; per-cancer scores at or above 0.5: lung cancer 0.51 (GraphQL API, CC0)"},{"label":"IntOGen DDX6","url":"https://www.intogen.org/search?gene=DDX6","note":"driver in 2 cohorts (Act 1, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"hgnc":"HGNC:2747","ensembl":"ENSG00000110367","uniprot":"P26196","entrez":"1656","biology":"Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation. In the process of mRNA degradation, plays a role in mRNA decapping. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts. Location: Cytoplasm, P-body; Cytoplasm; Nucleus; Cytoplasm, Cytoplasmic ribonucleoprotein granule (UniProt). Locus 11q23.3 (HGNC).","whereFound":["Sarcomas: IntOGen driver in 1 cohort (LMS)","Lung cancer: Open Targets association 0.51 with lung cancer (MONDO_0008903)","Leiomyosarcoma: IntOGen driver in 1 cohort (LMS)","Medulloblastoma: IntOGen driver in 1 cohort (MBL)"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/ddx6/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"leiomyosarcoma","kind":"cancer","name":"Leiomyosarcoma","route":"/cancers/leiomyosarcoma/"},{"id":"lung-cancer","kind":"cancer","name":"Lung cancer (all types)","route":"/cancers/lung-cancer/"},{"id":"medulloblastoma","kind":"cancer","name":"Medulloblastoma","route":"/cancers/medulloblastoma/"},{"id":"sarcoma","kind":"cancer","name":"Sarcomas (soft tissue, bone, GIST)","route":"/cancers/sarcoma/"}]}}