{"entity":{"id":"dek","kind":"target","name":"DEK","aka":["DEK proto-oncogene","D6S231E"],"tldr":"DEK (DEK proto-oncogene) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Gastric & gastro-oesophageal junction cancer.","summary":"Involved in chromatin organisation.\n\nOpen Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.00, somatic mutation 0.97).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:2768","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2768"},{"label":"UniProt P35659","url":"https://www.uniprot.org/uniprotkb/P35659/entry"},{"label":"NCBI Gene 7913","url":"https://www.ncbi.nlm.nih.gov/gene/7913"},{"label":"Ensembl ENSG00000124795","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000124795"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":["breast-cancer","gastric"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DEK","role":["fusion-partner"],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:2768","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2768","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt P35659","url":"https://www.uniprot.org/uniprotkb/P35659/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000124795","url":"https://platform.opentargets.org/target/ENSG00000124795/associations","note":"association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: gastric cancer 0.51, breast cancer 0.53 (GraphQL API, CC0)"}],"hgnc":"HGNC:2768","ensembl":"ENSG00000124795","uniprot":"P35659","entrez":"7913","biology":"Involved in chromatin organisation. Location: Nucleus (UniProt). Locus 6p22.3 (HGNC).","whereFound":["Breast cancer: Open Targets association 0.53 with breast cancer (MONDO_0007254)","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.51 with gastric cancer (MONDO_0001056)"],"targetClass":"other","prevalence":[]},"route":"/targets/dek/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"}]}}