{"entity":{"id":"dendritic-cell-vaccines","kind":"technology","name":"Dendritic cell vaccines","aka":[],"tldr":"Vaccines made from a patient's own antigen-presenting cells loaded with tumour proteins; sipuleucel-T for prostate cancer was the first approved, and newer versions are tested in brain and other cancers.","summary":"Dendritic cells present antigens to T cells. Sipuleucel-T, approved in 2010 for metastatic castration-resistant prostate cancer, loads the patient's antigen-presenting cells with a prostatic acid phosphatase fusion protein and reinfuses them, prolonging survival modestly. Later dendritic cell vaccines pulsed with tumour lysate or RNA have reached phase 3 in glioblastoma and are combined with checkpoint inhibitors, while off-the-shelf approaches try to target dendritic cells inside the body.","status":"approved","asOf":"2026-09-04","wikipedia":"https://en.wikipedia.org/wiki/Sipuleucel-T","links":[{"label":"Wikipedia","url":"https://en.wikipedia.org/wiki/Sipuleucel-T"}],"tags":[],"related":[],"cancers":["prostate","glioblastoma"],"sections":["immunotherapy"],"technologies":[],"targets":["pap"],"drugs":["sipuleucel-t"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"principle":"Leukapheresis harvests monocytes, which are matured into dendritic cells, loaded with antigen and reinfused to prime tumour-specific T cells.","strengths":["Proven survival benefit in prostate cancer","Personalised, low toxicity"],"limitations":["Costly, individual manufacturing","Modest response rates as single agents"],"since":2010},"route":"/technologies/dendritic-cell-vaccines/","neighbours":{"cancer":[{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"section":[{"id":"immunotherapy","kind":"section","name":"Immunotherapy","route":"/fronts/immunotherapy/"}],"target":[{"id":"pap","kind":"target","name":"Prostatic acid phosphatase (ACP3, PAP)","route":"/targets/pap/"}],"drug":[{"id":"sipuleucel-t","kind":"drug","name":"Sipuleucel-T","route":"/drugs/sipuleucel-t/"}]}}