{"entity":{"id":"denovo-biopharma","kind":"company","name":"Denovo Biopharma","aka":["Denovo Biopharma LLC"],"tldr":"Denovo is a San Diego biotech that revives failed drugs by finding the genetic marker of patients who did respond; it took enzastaurin back into phase 3 in lymphoma and glioblastoma with its DGM1 biomarker.","summary":"Denovo Biopharma, based in San Diego, licenses drugs that failed in unselected populations and re-tests them in patients selected by germline biomarkers it discovers. Its lead programme, enzastaurin (DB102) with the DGM1 marker, was taken into the phase 3 ENGINE trial in diffuse large B-cell lymphoma and a phase 3 trial in glioblastoma, both registered on ClinicalTrials.gov under Denovo as lead sponsor.","asOf":"2026-09-11","links":[{"label":"Official website","url":"https://denovobiopharma.com"},{"label":"ClinicalTrials.gov: trials led by Denovo Biopharma LLC","url":"https://clinicaltrials.gov/search?lead=Denovo%20Biopharma%20LLC"},{"label":"Wikidata","url":"https://www.wikidata.org/wiki/Q140046004"}],"tags":["ctgov-sponsor"],"related":[],"cancers":["dlbcl","glioblastoma"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":["pivotal-trial","clinical-trial"],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"notes":[],"provenance":{"editedBy":"OnCo ingestion (ClinicalTrials.gov v2 + sponsor websites)","editedOn":"2026-09-11"},"hq":"San Diego, CA","country":"US","companyType":"biotech","website":"https://denovobiopharma.com","stage":"private-large","investors":[],"funding":[]},"route":"/companies/denovo-biopharma/","neighbours":{"cancer":[{"id":"dlbcl","kind":"cancer","name":"Diffuse large B-cell lymphoma","route":"/cancers/dlbcl/"},{"id":"glioblastoma","kind":"cancer","name":"Glioma & glioblastoma","route":"/cancers/glioblastoma/"}],"term":[{"id":"clinical-trial","kind":"term","name":"Clinical trial","route":"/terms/clinical-trial/"},{"id":"pivotal-trial","kind":"term","name":"Pivotal (registrational) trial","route":"/terms/pivotal-trial/"}]}}